Department of Experimental and Clinical Medicine, University of Florence, Florence.
Head and Neck Oncology and Robotic Surgery, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Head Neck. 2022 Aug;44(8):1961-1975. doi: 10.1002/hed.27062. Epub 2022 Apr 20.
Recurrent salivary gland carcinomas (RSCs) are poorly characterized and their clinical features and treatment options have not yet been fully described. The goal of this study was to analyze the therapeutic strategies and oncological outcomes of RSC patients through a literature review analysis. This systematic review was performed according to the PRISMA statements. Inclusion criteria for the systematic review were based on the population, intervention, comparison, and outcomes according to (PICO) framework. Two thousand seven hundred and four records were selected and 1817 recurrences were studied. Three hundred and sixty-five patients underwent salvage surgery (20.1%) and their 5-year mortality rate, overall survival and disease-free survival were 35%, 70%, and 42%, respectively. RSCs are aggressive neoplasms with a high rate of distant metastases (28.9%). Salvage surgery can be considered in patients with limited local and/or regional recurrences, even in case of single distant relapse, appearing within the first 3 years of follow-up.
复发性唾液腺癌 (RSCs) 的特征不明显，其临床特征和治疗选择尚未完全描述。本研究的目的是通过文献回顾分析来分析 RSC 患者的治疗策略和肿瘤学结果。本系统评价是根据 PRISMA 声明进行的。系统评价的纳入标准是根据人群、干预、比较和结果（PICO）框架。共筛选出 2704 条记录，研究了 1817 次复发。365 例患者接受了挽救性手术（20.1%），其 5 年死亡率、总生存率和无病生存率分别为 35%、70%和 42%。RSCs 是具有高远处转移率（28.9%）的侵袭性肿瘤。对于局部和/或区域复发有限的患者，甚至对于在随访的前 3 年内出现的单发远处复发患者，可考虑进行挽救性手术。
