采用微波促进脱保护策略将 4,4-二氟-4-硼-3a,4a-二氮杂-s-茚并（F-BODIPYs）转化为二吡咯甲烷。
Conversion of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes (F-BODIPYs) to dipyrrins with a microwave-promoted deprotection strategy.
机构信息
Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, B3H 4J3, Canada.
出版信息
Org Lett. 2010 Apr 2;12(7):1424-7. doi: 10.1021/ol902908j.
PMID:20192207
Abstract
4,4-Difluoro-4-bora-3a,4a-diaza-s-indacenes (F-BODIPYs) have been deprotected to give the corresponding free-base dipyrrins by heating a solution of the F-BODIPY in tert-butanol under 600 W of microwave irradiation in the presence of 6 equiv of potassium tert-butoxide for 40 min at 92 degrees C. Investigations of BODIPY modification at the meso position have also been undertaken and a meso-butyl product has been isolated.
摘要
4,4-二氟-4-硼-3a,4a-二氮杂-s-茚并（F-BODIPYs）通过在 600 W 的微波辐射下，将 F-BODIPY 在叔丁醇中的溶液加热 40 分钟，在 92 摄氏度下，在 6 当量的叔丁醇钾存在下，脱保护得到相应的游离碱基二吡咯并[3,4-f]吡咯。还对 BODIPY 在中位位置的修饰进行了研究，并分离出了一个中位丁基产物。
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