Buckland-Wright J C, Macfarlane D G, Fogelman I, Emery P, Lynch J A
Department of Anatomy, United Medical School of Guy's, London Bridge, UK.
Eur J Nucl Med. 1991;18(1):12-6. doi: 10.1007/BF00177678.
In this prospective study, the radiological features characteristic of osteoarthritis of the hand were compared with the radionuclide bone scan images. A total of 32 patients was assessed at 6-monthly intervals for 18 months. Microfocal radiographs were taken at each visit. The high magnification and resolution of this technique permitted direct measurement of joint space width, subchondral sclerosis, osteophyte number and area and juxta-articular radiolucency area for each joint in the hand. Four-hour technetium 99m methylene diphosphonate bone scans were taken at 0 and 12 months and the activity of tracer uptake at each joint scored. The latter was compared with each X-radiographic feature at every visit and the changes between visits analysed. The scan scores did not correlate with any of the X-radiographic features other than osteophyte size. During the study the size of growing and remodelling osteophytes increased significantly at joints with raised or increased isotope uptake.
在这项前瞻性研究中，将手部骨关节炎的放射学特征与放射性核素骨扫描图像进行了比较。共有32例患者接受了为期18个月、每6个月一次的评估。每次就诊时均拍摄微焦点X线片。该技术的高放大率和分辨率使得能够直接测量手部每个关节的关节间隙宽度、软骨下硬化、骨赘数量和面积以及关节周围透亮区面积。在0个月和12个月时进行4小时的锝99m亚甲基二膦酸盐骨扫描，并对每个关节的示踪剂摄取活性进行评分。将后者与每次就诊时的每个X线特征进行比较，并分析就诊之间的变化。扫描评分与除骨赘大小外的任何X线特征均无相关性。在研究期间，同位素摄取增加或升高的关节处，正在生长和重塑的骨赘大小显著增加。
