ILT7 的信号转导和配体相互作用：浆细胞样树突状细胞的受体介导的调节机制。
Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells.
机构信息
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
出版信息
Immunol Rev. 2010 Mar;234(1):163-76. doi: 10.1111/j.0105-2896.2009.00867.x.
Abstract
Plasmacytoid dendritic cells (pDCs) are specialized dendritic cells (DCs) that produce large amounts of type I interferon (IFN) after Toll-like receptor (TLR) activation. Human pDCs preferentially express immunoglobulin-like transcript 7 (ILT7; LILRA4), which couples with a signaling adapter to activate a prominent immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling pathway. ILT7 protein directly binds to and can be activated by bone marrow stromal cell antigen 2 (BST2; CD317) protein, the expression of which is found on cells pre-exposed to IFN or on the surface of human cancer cells. The interaction between ILT7 and BST2 functions to assure an appropriate TLR response by pDCs during viral infection and likely participates in pDC-tumor crosstalk. Two opposing modes of receptor-mediated regulatory mechanisms work jointly to fine tune the innate immunity of pDCs.
摘要
浆细胞样树突状细胞 (pDCs) 是一种特化的树突状细胞 (DCs)，在 Toll 样受体 (TLR) 激活后会产生大量的 I 型干扰素 (IFN)。人类 pDCs 优先表达免疫球蛋白样转录物 7 (ILT7; LILRA4)，它与信号适配器结合，激活一个显著的免疫受体酪氨酸基激活基序 (ITAM) 介导的信号通路。ILT7 蛋白直接结合并可被骨髓基质细胞抗原 2 (BST2; CD317) 蛋白激活，该蛋白在预先暴露于 IFN 的细胞或人类癌细胞表面表达。ILT7 和 BST2 之间的相互作用可确保 pDCs 在病毒感染期间对 TLR 做出适当的反应，并且可能参与 pDC-肿瘤串扰。两种相反的受体介导的调节机制模式共同作用，精细调节 pDCs 的先天免疫。
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本文引用的文献
1
2
Pillars article: antigen receptor tail clue. Nature. 1989. 338: 383-384.专栏文章：抗原受体尾部线索。《自然》。1989年。第338卷：第383 - 384页。
J Immunol. 2014 May 1;192(9):4015-6.
3
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.RNA聚合酶III可检测胞质DNA，并通过RIG-I途径诱导I型干扰素产生。
Cell. 2009 Aug 7;138(3):576-91. doi: 10.1016/j.cell.2009.06.015. Epub 2009 Jul 23.
4
Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction.通过BST2与ILT7受体相互作用对浆细胞样树突状细胞中TLR7/9反应的调节。
J Exp Med. 2009 Jul 6;206(7):1603-14. doi: 10.1084/jem.20090547. Epub 2009 Jun 29.
5
Approaching the asymptote: 20 years later.接近渐近线：20年后。
Immunity. 2009 Jun 19;30(6):766-75. doi: 10.1016/j.immuni.2009.06.004.
6
HBsAg inhibits TLR9-mediated activation and IFN-alpha production in plasmacytoid dendritic cells.乙肝表面抗原抑制浆细胞样树突状细胞中Toll样受体9介导的激活作用及α干扰素的产生。
Mol Immunol. 2009 Aug;46(13):2640-6. doi: 10.1016/j.molimm.2009.04.031. Epub 2009 Jun 5.
7
IFN-alpha wakes up sleeping hematopoietic stem cells.干扰素-α唤醒休眠的造血干细胞。
Nat Med. 2009 Jun;15(6):612-3. doi: 10.1038/nm0609-612.
8
Pathogen recognition in the innate immune response.天然免疫反应中的病原体识别
Biochem J. 2009 Apr 28;420(1):1-16. doi: 10.1042/BJ20090272.
9
Regulation of T-cell immunity by leucocyte immunoglobulin-like receptors: innate immune receptors for self on antigen-presenting cells.白细胞免疫球蛋白样受体对T细胞免疫的调节：抗原呈递细胞上的自身固有免疫受体。
Immunology. 2009 May;127(1):8-17. doi: 10.1111/j.1365-2567.2009.03097.x.
10
HM1.24 is internalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptin.HM1.24通过与α-衔接蛋白相互作用，经网格蛋白介导的内吞作用从脂筏内化。
J Biol Chem. 2009 Jun 5;284(23):15927-41. doi: 10.1074/jbc.M109.005124. Epub 2009 Apr 8.
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