Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20894, USA.
Immunol Rev. 2010 Mar;234(1):305-16. doi: 10.1111/j.0105-2896.2009.00880.x.
Each microenvironment is controlled by a specific set of regulatory elements that have to be finely and constantly tuned to maintain local homeostasis. These environments could be site specific, such as the gut environment, or induced by chronic exposure to microbes. Various populations of dendritic cells are central to the orchestration of this control. In this review, we discuss some new findings associating dendritic cells from defined compartments with the induction and control of regulatory T cells in the context of exposure to both commensal and pathogenic microbes.
每个微环境都受到特定的调控元件的控制,这些元件必须精确而持续地调整,以维持局部的体内平衡。这些环境可以是特定部位的,如肠道环境,也可以是由长期接触微生物引起的。各种树突状细胞群体是这种控制的核心。在这篇综述中,我们讨论了一些新的发现,将来自特定部位的树突状细胞与在接触共生菌和致病菌时诱导和控制调节性 T 细胞联系起来。