Zhang Ying, Wang Jian
Department of Gynaecology and Obstetrics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710033, P.R. China.
Chin J Cancer. 2010 Mar;29(3):333-9. doi: 10.5732/cjc.009.10285.
Apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1), as a type of multifunctional protein, plays an essential role in the base excision repair (BER) pathway, which is responsible for the repair of DNA caused by oxidative and alkylation damage. As importantly, APE/Ref-1 also functions as a redox factor maintaining transcription factors in an active reduced state. APE/Ref-1 stimulates the DNA-binding activity of numerous transcription factors that are involved in cancer promotion and progression, such as AP-1 (Fos/Jun), NF-kappaB, HIF-1alpha, p53, and others. Based on the structures and functions of APE1/Ref-1, we will provide an overview of its activities and explore the budding clinical use of this protein as a target in cancer treatment, and propose that APE/Ref-1 has a great potential for application in clinical research.
脱嘌呤/脱嘧啶内切核酸酶/氧化还原因子-1（APE/Ref-1）作为一种多功能蛋白，在碱基切除修复（BER）途径中发挥着重要作用，该途径负责修复由氧化和烷基化损伤引起的DNA。同样重要的是，APE/Ref-1还作为一种氧化还原因子，使转录因子维持在活性还原状态。APE/Ref-1刺激众多参与癌症发生和发展的转录因子的DNA结合活性，如AP-1（Fos/Jun）、核因子-κB、缺氧诱导因子-1α、p53等。基于APE1/Ref-1的结构和功能，我们将概述其活性，并探讨该蛋白作为癌症治疗靶点的新兴临床应用，提出APE/Ref-1在临床研究中具有巨大的应用潜力。
