Liu Ya-qi, Xu Yi-zhuang, Sun Qi-gang, Zhang Xiao-qing, Xu Zhi, Zhang Yuan-fu, Wu Jin-guang, Zhou Xiao-si, Ling Xiao-feng
Department of General Surgery, Peking University Third Hospital, Beijing 100191, China.
Zhonghua Zhong Liu Za Zhi. 2009 Dec;31(12):908-10.
To explore a novel non-invasive method in detection of thyroid cancer by Fourier transform infrared (FTIR) spectroscopy.
Surface FTIR spectra of 15 cases of thyroid cancer and 51 cases of normal subjects were collected. 22 variables of 11 bands including peak positions and relative intensities were measured and all data were statistically analyzed.
In the cancer group: (1) the peak position of 1743 cm(-1) was shifted toward higher wave number (P < 0.05), and that of 1250 cm(-1) to the lower (P < 0.05), when compared to those of normal ones. (2) The relative intensity ratios of I(1546)/I(1460), I(1250)/I(1460), I(1120)/I(1460), I(1080)/I(1460) were significantly increased (P < 0.05). (3) The presence rate of band of 1340 cm(-1) was significantly decreased (P < 0.05).
FTIR surface spectra may become a novel powerful non-invasive approach of detecting thyroid cancer in regular routine check-up.
探索一种通过傅里叶变换红外（FTIR）光谱检测甲状腺癌的新型非侵入性方法。
收集15例甲状腺癌患者和51例正常受试者的表面FTIR光谱。测量11个波段的22个变量，包括峰位和相对强度，并对所有数据进行统计分析。
在癌症组中：（1）与正常组相比，1743 cm(-1)的峰位向高波数移动（P < 0.05），1250 cm(-1)的峰位向低波数移动（P < 0.05）。（2）I(1546)/I(1460)、I(1250)/I(1460)、I(1120)/I(1460)、I(1080)/I(1460)的相对强度比显著增加（P < 0.05）。（3）1340 cm(-1)波段的出现率显著降低（P < 0.05）。
FTIR表面光谱可能成为定期常规检查中检测甲状腺癌的一种新型有力的非侵入性方法。
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