Feng Wen-li, Yang Jing, Xi Zhi-qin, Wang Yan-qing, Zhang Run-mei, Ji Ying, Wu Yuan, Jia Xiao-qiang
Department of Dermatovenereology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Oct;30(10):1043-6.
To investigate the epidemiological features of patients with nosocomial invasive fungal infection.
Fungi in blood were identified by BacT ALERT 3D, other clinical samples were cultured by Sabouraud's dextrose agar (SDA) medium. Candidas were isolated and identified by CHRO Magar candida color medium. Fungus-cultured positive cases from Jan. 2004 to Nov. 2007 were analyzed on items as patients' age, underlying disease, sample, strain, and species distribution. All statistical analyses were carried out by SPSS 13.0.
The overall incidence rate of invasive fungal infections was 4.12%. The average age of patients was 7 - 96 with most patients were male, with geriatric problems and different kinds of underlying diseases. Lower respiratory tract infection was the most frequent infection site, followed by urinary tract, gastrointestinal tract. The main pathogens of invasive fungal infections were Candidas (93.80%). Strains of Candida albicans were the most frequent organisms which accounted for 67.29% of all the isolates. Mould fungus infections accounted for only 6.20%. During the 4 years of observation, the detection rate of fungi, specimen sources and the distribution of species and compartment were different with significant differences (P < 0.0083).
The epidemiological properties such as the source of specimen, the distribution of species and composition sections of invasive fungal infections were changing. Candida spp. were still the main pathogens of invasive fungal infections but the sections of fungi changed. The incidence of Aspergillus infections had been increasing recently.
探讨医院获得性侵袭性真菌感染患者的流行病学特征。
采用BacT ALERT 3D对血液中的真菌进行鉴定，其他临床标本用沙氏葡萄糖琼脂（SDA）培养基培养。念珠菌采用CHRO Magar念珠菌显色培养基进行分离鉴定。对2004年1月至2007年11月真菌培养阳性病例的患者年龄、基础疾病、标本、菌株及菌种分布等项目进行分析。所有统计分析均采用SPSS 13.0软件进行。
侵袭性真菌感染的总发生率为4.12%。患者平均年龄7～96岁，以男性居多，有老年问题及多种基础疾病。下呼吸道感染是最常见的感染部位，其次为泌尿系统、胃肠道。侵袭性真菌感染的主要病原菌为念珠菌（93.80%）。白色念珠菌菌株是最常见的菌株，占所有分离株的67.29%。霉菌感染仅占6.20%。在4年的观察期间，真菌的检出率、标本来源及菌种和菌属分布存在差异，差异有统计学意义（P<0.0083）。
侵袭性真菌感染的标本来源、菌种分布及菌属构成等流行病学特征在发生变化。念珠菌仍是侵袭性真菌感染的主要病原菌，但真菌菌属发生了变化。近年来曲霉感染的发生率呈上升趋势。
