Cao Fei-fei, Chen Xing-dong, Wang Qun-shan, Li Lei, Wang Xiao-feng, Lu Ming, Jin Li
Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan 250012, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Oct;30(10):1069-72.
To investigate whether polymorphisms in CYP11B2 gene are associated with nonfamilial structural atrial fibrillation (AF) in Chinese Han population.
A fine-designed pair-matched hospital based case-control study was performed in 297 cases and 297 controls. We investigated two tagging single nucleotide polymorphisms (tSNPs)-rs4545, rs3802228 in CYP11B2 gene by using GenomeLab SNPstream technique.
Two tSNPs were consistent with Hardy-Weinberg expectations in case and control groups. Compared with controls, the left atrial diameter of cases was significantly higher (P < 0.0001). No significant difference in genotype or allele frequencies of tSNPs in CYP11B2 gene was observed. However, at the site of rs3802228 in 3'UTR of the case group, the left atrial diameter in AF patients with GG genotype was significantly higher than others. After adjusted for covariates age, smoking, Body mass index and hypertension, we did not observe the association of rs4545, rs3802228 with AF.
Our result suggested that polymorphisms of rs4545 in CYP11B2 gene might not be associated with atrial fibrillation but polymorphism of 3'UTR rs3802228 locus in CYP11B2 gene might be associated with atrial structural remodeling.
研究CYP11B2基因多态性是否与中国汉族人群非家族性结构性心房颤动（AF）相关。
进行一项精心设计的基于医院的病例对照配对研究，纳入297例病例和297例对照。采用GenomeLab SNPstream技术研究CYP11B2基因中的两个标签单核苷酸多态性（tSNP）——rs4545、rs3802228。
两个tSNP在病例组和对照组中均符合Hardy-Weinberg平衡。与对照组相比，病例组的左心房直径显著更高（P<0.0001）。未观察到CYP11B2基因tSNP的基因型或等位基因频率有显著差异。然而，在病例组3'UTR的rs3802228位点，GG基因型的AF患者左心房直径显著高于其他患者。在调整协变量年龄、吸烟、体重指数和高血压后，未观察到rs4545、rs3802228与AF的关联。
我们的结果表明，CYP11B2基因rs4545多态性可能与心房颤动无关，但CYP11B2基因3'UTR rs3802228位点多态性可能与心房结构重塑有关。
