Department of Obstetrics and Gynaecology, Peking University Third Hospital, Beijing 100083, China.
Chin Med J (Engl). 2010 Feb 20;123(4):418-22.
Congenital uterine anomalies are associated with the highest incidence of reproductive failure and obstetric complications. This study aimed to summarize the clinical characteristics and prenatal outcome of pregnancy in women with congenital uterine malformations.
This retrospective study evaluated the fertility and obstetric outcome of 116 inpatients with uterine malformations with pregnancy in Peking University Third Hospital from June 1998 to June 2009. A total of 270 randomly selected pregnant women with a previously confirmed normally shaped uterus as a control group. Student's t test and analysis of variance (ANOVA) were used to compare means for normally distributed variables. The analysis was carried out using the SPSS.
Among 21 961 deliveries in Peking University Third Hospital, 116 (0.45%) were in women with uterine anomalies. A septate uterus was present in 43 (37.1%) and the uterus didelphys in 28 (24.2%) of the 116 women identified. Bicornuate uterus, arcuate and unicomate uterus were observed in 12 (10.3%), 18 (15.5%) and 15 (12.9%) patients, respectively. Patients with uterine anomalies had significantly higher rates of malpresentation (38.8%), preterm delivery (19.8%), and cesarean section (78.5%) compared with the group of women with a normal uterus. Patients with uterine anomalies had significantly lower mean birth-weight neonates and a significantly higher incidence of small for gestationalage (SGA) neonates; women with uterus didelphys more frequently required infertility treatment than patients with other uterine anomalies (P < 0.001). The rate of malpresentation was significantly higher in patients with septated uterus in comparison with patients with uterus unicorns (P < 0.05).
Women with congenital uterinemal formation usually have higher incidence of complications during pregnancy and delivery. A septate uterus appears to be associated with poorer obstetric outcomes.
先天性子宫畸形与生殖失败和产科并发症的发生率最高有关。本研究旨在总结先天性子宫畸形女性妊娠的临床特征和产前结局。
本回顾性研究评估了 1998 年 6 月至 2009 年 6 月期间北京大学第三医院 116 例子宫畸形伴妊娠的住院患者的生育和产科结局。共选择 270 例先前确诊为正常子宫形态的妊娠妇女作为对照组。对于正态分布的变量，采用学生 t 检验和方差分析（ANOVA）进行比较均值。分析采用 SPSS 进行。
在北京大学第三医院的 21961 例分娩中，有 116 例（0.45%）为子宫畸形妇女。116 例患者中，纵隔子宫 43 例（37.1%），双子宫 28 例（24.2%）。双角子宫、弓形子宫和单角子宫分别为 12 例（10.3%）、18 例（15.5%）和 15 例（12.9%）。与正常子宫组相比，子宫畸形患者胎位不正（38.8%）、早产（19.8%）和剖宫产（78.5%）的发生率明显更高。子宫畸形患者新生儿的平均出生体重明显较低，小于胎龄儿（SGA）的发生率明显较高；与其他子宫畸形患者相比，双子宫患者更常需要不孕治疗（P <0.001）。与单角子宫患者相比，纵隔子宫患者胎位不正的发生率明显更高（P <0.05）。
先天性子宫畸形女性妊娠时通常并发症发生率较高。纵隔子宫似乎与较差的产科结局相关。
