Wang Xia, Ding Xin-ping, Su Bin, Xu Chen, Liu Yuan, Zhang Yan-min, Zhu Jun-ling, Han Li-tao, Ruan Yu-hua, Shao Yi-ming
School of Public Health, Peking Union Medical College, Beijing 100730, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Nov;30(11):1135-8.
To estimate the median survival and the effect of antiretroviral therapy (ART) among HIV-positive former blood donors of Fuyang in Anhui province, China.
A retrospective survey was conducted among HIV-positive former blood donors, and data was collected on survivors who had received ART. Weibull function was used to calculate median survival of HIV-positive former blood donors. The effect of ART was estimated through comparing the actual number of deaths after ART with the expected number of deaths in those who did not receive ART.
The median period of HIV infection was at the end of 1994, with the median survival of HIV-positive former blood donors in Fuyang as 10.8 years. By the end of September 2008, among 159 former blood donors, 74 received ART, with their mean CD(4)(+) T-cell count increased from 247.8/microl to 475.1/microl (P < 0.0001). 76 of the 159 former blood donors died. When comparing the expected number of deaths calculated by Weibull function, 31.7% of the total number of deaths was reduced.
Result from this study was in consistent to the UNAIDS' figures that in the absence of treatment, the net median survival time after infection with HIV was estimated to be 11 years and ART has reduced about one third of the expected deaths.
评估中国安徽省阜阳市既往献血的HIV阳性者的中位生存期以及抗逆转录病毒疗法（ART）的效果。
对既往献血的HIV阳性者进行回顾性调查，收集接受ART治疗的幸存者的数据。采用威布尔函数计算既往献血的HIV阳性者的中位生存期。通过比较ART治疗后的实际死亡人数与未接受ART治疗者的预期死亡人数来评估ART的效果。
HIV感染的中位时间为1994年末，阜阳市既往献血的HIV阳性者的中位生存期为10.8年。截至2008年9月底，159名既往献血者中，74人接受了ART治疗，其CD4+T细胞平均计数从247.8/μl增至475.1/μl（P<0.0001）。159名既往献血者中有76人死亡。与威布尔函数计算的预期死亡人数相比，总死亡人数减少了31.7%。
本研究结果与联合国艾滋病规划署的数据一致，即在未接受治疗的情况下，HIV感染后的净中位生存时间估计为11年，而ART使预期死亡人数减少了约三分之一。
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