促肾上腺皮质素释放因子介导大鼠酒精戒断相关的快感缺失状态。
Corticotropin-releasing factor mediates the dysphoria-like state associated with alcohol withdrawal in rats.
机构信息
Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA.
出版信息
Behav Brain Res. 2010 Jul 11;210(2):288-91. doi: 10.1016/j.bbr.2010.02.043. Epub 2010 Mar 1.
Abstract
This study investigated the role of CRF in the dysphoria-like state associated with alcohol withdrawal in rats. The intracranial self-stimulation procedure was used to assess brain reward thresholds. Cessation of chronic alcohol administration led to an elevation in brain reward thresholds in the alcohol dependent rats. The CRF receptor antagonist D-Phe CRF((12-41)) dose-dependently prevented the elevations in brain reward thresholds associated with alcohol withdrawal. This indicates that the dysphoria associated with alcohol withdrawal is at least partly mediated by the activation of central CRF receptors.
摘要
本研究旨在探讨 CRF 在大鼠酒精戒断相关抑郁样状态中的作用。采用颅内自我刺激程序来评估大脑奖赏阈值。慢性酒精给药的停止导致酒精依赖大鼠的大脑奖赏阈值升高。CRF 受体拮抗剂 D-Phe CRF((12-41)) 剂量依赖性地预防了与酒精戒断相关的大脑奖赏阈值升高。这表明与酒精戒断相关的抑郁至少部分是由中枢 CRF 受体的激活介导的。
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