立体选择性合成生物活性天然螺缩酮 aculeatins A 和 B。

Stereoselective synthesis of bioactive natural spiroacetals aculeatins A and B.

机构信息

Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500007, India.

出版信息

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2303-5. doi: 10.1016/j.bmcl.2010.01.162. Epub 2010 Feb 10.

DOI:10.1016/j.bmcl.2010.01.162

PMID:20194022

Abstract

The stereoselective synthesis of two naturally occurring bioactive spiroacetals, aculeatins A and B has been accomplished using 1-tetradecanal as the starting material. The sequence introduces diastereoselective iodine-induced electrophilic cyclization and ring opening of epoxide with 1,3-dithiane as the key steps.

摘要

两种天然生物活性螺缩醛 aculeatins A 和 B 的立体选择性合成已经完成，使用 1-十四醛作为起始原料。该序列介绍了非对映选择性碘诱导的亲电环化和环氧与 1,3-二噻烷的开环反应，这是关键步骤。