Tomova Elena S, Sarafian Victoria S
Department of Developmental Biology, University of Plovdiv P. Hilendarski, 24 Tsar Assen Str., Plovdiv 4000, Bulgaria.
Acta Biol Hung. 2010 Mar;61(1):64-72. doi: 10.1556/ABiol.61.2010.1.7.
The tissue expression of human histo-blood group antigens (HBGA) in vertebrates, as well as their evolutionary tendencies and relation to histogenesis, especially in the reproductive system, are not entirely understood.The present research comprises a large-scale immunohistochemical study of HBGA A and B expression in ovaries and testicles of 14 species belonging to six classes of free-living vertebrates from Chondrichtyes to Mammalia .We present novel data for ABH antigen reactivity in reproductive organs of vertebrates which have not been studied so far. Our results suggest that HBGA are evolutionary stable structures, most possibly related to vitellogenesis in oocytes with high yolk content. The tendency observed in A and B antigen expression is mostly associated with the processes of gamete differentiation and vitellogenesis, rather than with the evolutionary development of vertebrate species.
人类组织血型抗原（HBGA）在脊椎动物中的组织表达，以及它们的进化趋势和与组织发生的关系，尤其是在生殖系统中的关系，目前尚未完全明确。本研究包括一项大规模免疫组织化学研究，对属于从软骨鱼纲到哺乳纲六类自由生活脊椎动物的14个物种的卵巢和睾丸中HBGA A和B的表达进行了研究。我们提供了迄今为止尚未研究过的脊椎动物生殖器官中ABH抗原反应性的新数据。我们的结果表明，HBGA是进化稳定的结构，极有可能与高卵黄含量卵母细胞中的卵黄生成有关。在A和B抗原表达中观察到的趋势主要与配子分化和卵黄生成过程相关，而非与脊椎动物物种的进化发展相关。
