Metabolism Unit, Laboratory of Clinical Investigation, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.
Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6127-33. doi: 10.1073/pnas.0912955107. Epub 2010 Mar 1.
Failure to recognize that many standard control rats and mice used in biomedical research are sedentary, obese, glucose intolerant, and on a trajectory to premature death may confound data interpretation and outcomes of human studies. Fundamental aspects of cellular physiology, vulnerability to oxidative stress, inflammation, and associated diseases are among the many biological processes affected by dietary energy intake and exercise. Although overfed sedentary rodents may be reasonable models for the study of obesity in humans, treatments shown to be efficacious in these animal models may prove ineffective or exhibit novel side effects in active, normal-weight subjects.
未能认识到，许多在生物医学研究中使用的标准的对照大鼠和小鼠都是久坐不动、肥胖、葡萄糖不耐受，并处于过早死亡的轨迹上，这可能会混淆数据解释和人类研究的结果。细胞生理学的基本方面、对氧化应激、炎症和相关疾病的易感性是受饮食能量摄入和运动影响的众多生物学过程之一。虽然过度喂养的久坐不动的啮齿动物可能是研究人类肥胖的合理模型，但在这些动物模型中显示有效的治疗方法在活跃的、正常体重的受试者中可能无效或表现出新的副作用。
