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两剂甲型肝炎灭活疫苗接种后的长期免疫效果,在阿根廷儿童中。

Long-term immunity after two doses of inactivated hepatitis A vaccine, in Argentinean children.

机构信息

Infectious Diseases Program, Hospital de Niños Dr. Ricardo Gutiérrez, Buenos Aires, Argentina.

出版信息

Pediatr Infect Dis J. 2010 Jun;29(6):568-70. doi: 10.1097/INF.0b013e3181d57a85.

DOI:10.1097/INF.0b013e3181d57a85
PMID:20195189
Abstract

We examined long-term anti-hepatitis A virus antibody persistence in Argentinean children 10 years after the initial study in which they received 2 doses of inactivated hepatitis A vaccine (Avaxim 80U). Of the 111 children, 48 from the initial trial were enrolled. Of 48, 47 (97.9%) participants had serum anti-hepatitis A virus antibody titers > or =20 mIU/mL, with the geometric mean concentration of 390.91 (+/-370.14) mIU/mL; (95% confidence interval, 282.2-499.5 mIU/mL), range, 36 to 1860.

摘要

我们在阿根廷儿童接种两剂甲型肝炎灭活疫苗(Avaxim 80U)10 年后,对他们的长期抗甲型肝炎病毒抗体持久性进行了研究。在最初的研究中,有 111 名儿童,其中 48 名参加了本次研究。在这 48 名儿童中,47 名(97.9%)参与者的血清抗甲型肝炎病毒抗体滴度>或=20 mIU/mL,几何平均浓度为 390.91(+/-370.14)mIU/mL;(95%置信区间,282.2-499.5 mIU/mL),范围为 36 至 1860。

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