Center for Advanced Biomedical Science, TWIns, Waseda University, Tokyo, Japan.
Ann Biomed Eng. 2010 Jul;38(7):2302-13. doi: 10.1007/s10439-010-9978-5. Epub 2010 Mar 2.
Hypoplastic left heart syndrome (HLHS) is a congenital heart disease which should be treated at neonate. Even now, its operation is one of the greatest challenges. However, currently there are no quantitative standards to evaluate and predict the outcome of the therapy. In this study, computational fluid dynamics (CFD) was used to estimate the performance of first stage HLHS surgery, the Norwood operation. An image data transfer system was developed to convert clinical images into three-dimensional geometry. To confirm software applicability, a validation process was carried out to eliminate any influence of numerical procedures. The velocities derived from echocardiography measurements were used as boundary conditions, and pressure waves measured by a cardiac catheter simultaneous with an electrocardiogram (ECG) were employed to validate the results of CFD simulation. Calculated results were congruent with the in vivo measurement results. The blood flow circulations were successfully simulated and the distribution of blood flow in each vessel was estimated. Time-varying energy losses (EL), local pressure and wall shear stress (WSS) were analyzed to estimate clinical treatment. The results indicated that pulsatile simulation is essential in quantitative evaluation. Computational hemodynamics may be applied in the surgical optimization for the treatment of HLHS.
左心发育不全综合征（HLHS）是一种先天性心脏病，应在新生儿期进行治疗。即使是现在，它的手术也是最大的挑战之一。然而，目前还没有定量标准来评估和预测治疗的结果。在这项研究中，计算流体动力学（CFD）被用于评估第一阶段 HLHS 手术，即 Norwood 手术的效果。开发了一种图像数据传输系统，将临床图像转换为三维几何形状。为了确认软件的适用性，进行了验证过程，以消除数值程序的任何影响。从超声心动图测量中得出的速度被用作边界条件，同时通过与心电图（ECG）同步的心脏导管测量压力波，以验证 CFD 模拟的结果。计算结果与体内测量结果一致。成功地模拟了血流循环，并估计了每个血管中的血流分布。分析时变能量损失（EL）、局部压力和壁面切应力（WSS）以评估临床治疗。结果表明，脉动模拟在定量评估中至关重要。计算血液动力学可能应用于 HLHS 治疗的手术优化中。
