Department of Cardiac Surgery, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, People's Republic of China.
Department of Radiology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, People's Republic of China.
Cardiovasc Eng Technol. 2022 Oct;13(5):725-734. doi: 10.1007/s13239-022-00613-7. Epub 2022 Mar 1.
To build a fluid-structure interaction model of pulmonary veins with total anomalous pulmonary venous connection, which can be used to predict the result of surgical treatment and at the same time to estimate the elastic properties of pulmonary veins based on patient-specific data and clinic postoperative results.
The fluid-structure interaction (FSI) model was used to simulate the anastomosis on pulmonary veins based on computed tomography angiography data collected from three children with total anomalous pulmonary venous connection (TAPVC), supra-cardiac type. The deformation and the stress of anastomosis, and also the velocity of blood flow were calculated in fluid-structure coupling algorithm. During the simulation the variable boundary conditions were applied, including the thickness of vessel wall and the vessel elasticity for which was selected a range of values. The calculation results were finally compared to postoperative results of same patients and discussed. The corresponding outcomes are given in the conclusions section.
The blood flow velocity through the outlet will vary depending on the properties of vessels, including physical properties and thickness of vessel wall. The stress on vessel is lower for smaller values of Young's modulus. The calculated blood flow velocity correlates well with the postoperative results for the Young's modulus of vessels ranging from 0.5 to 1.0 MPa.
The FSI model has high potential to predict the result of surgery for TAPVC and to estimate the physical properties of pulmonary vein. This model also has potential to guide the strategy for surgical treatment.
建立完全性肺静脉异位连接的肺静脉流固耦合模型，用于预测手术治疗效果，并根据患者的具体数据和临床术后结果，估算肺静脉的弹性特性。
利用流体-结构相互作用（FSI）模型，基于 3 例完全性肺静脉异位连接（TAPVC）、心上型患者的计算机断层血管造影（CTA）数据，模拟肺静脉吻合。在流固耦合算法中计算吻合口的变形和应力，以及血流速度。在模拟过程中应用了可变边界条件，包括血管壁厚度和血管弹性，其中选择了一系列值。最后将计算结果与同一患者的术后结果进行比较和讨论。相应的结果在结论部分给出。
通过出口的血流速度将取决于血管的特性，包括血管壁的物理性质和厚度。杨氏模量越小，血管上的应力越低。对于血管杨氏模量在 0.5 至 1.0 MPa 范围内，计算出的血流速度与术后结果相关性良好。
FSI 模型具有预测 TAPVC 手术结果和估算肺静脉物理特性的巨大潜力。该模型还有助于指导手术治疗策略。
