设计和合成 3'-氟喷昔洛韦类似物作为抗病毒药物。
Design and synthesis of 3'-fluoropenciclovir analogues as antiviral agents.
机构信息
College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea.
出版信息
Arch Pharm Res. 2010 Feb;33(2):197-202. doi: 10.1007/s12272-010-0202-9. Epub 2010 Feb 24.
Based on fluorine switch approach, a series of 3'-fluoropenciclovir analogues with different purine and pyrimidine bases were designed and synthesized. Direct reduction of beta-fluoroester to the corresponding 3-fluoroalcohol provided an easy and new entry pathway towards the synthesis of 3'-fluoropenciclovir analogues. The synthesized 3'-fluoropenciclovir analogues were evaluated for their antiviral activities against the poliovirus, HSV-1, HSV-2 and HIV.
基于氟开关方法，设计并合成了一系列具有不同嘌呤和嘧啶碱基的 3'-氟喷昔洛韦类似物。β-氟酯直接还原为相应的 3-氟醇，为 3'-氟喷昔洛韦类似物的合成提供了一种简单而新颖的途径。合成的 3'-氟喷昔洛韦类似物被评估了对脊髓灰质炎病毒、HSV-1、HSV-2 和 HIV 的抗病毒活性。
Zotero 插件