Jahnz-Wechmann Zofia, Boryski Jerzy, Izawa Kunisuke, Onishi Tomoyuki, Neyts Johan, De Clercq Erik
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):917-20. doi: 10.1080/15257770701506442.
A series of novel analogs of acyclovir, substituted with an alkyl (methyl, ethyl, n-butyl) or phenyl group at the positions 1', 4', and/or 5', has been obtained in a direct one-pot coupling reaction of guanosine and the respective 1,3-dioxolanes. The new acyclonucleosides were essentially inactive in antiviral (HSV, VV, VSV, HBV) evaluation in vitro.
通过鸟苷与相应的1,3 - 二氧戊环的直接一锅法偶联反应，已获得了一系列阿昔洛韦的新型类似物，它们在1'、4'和/或5'位被烷基（甲基、乙基、正丁基）或苯基取代。这些新的无环核苷在体外抗病毒（单纯疱疹病毒、痘苗病毒、水疱性口炎病毒、乙肝病毒）评估中基本无活性。
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