Schmidtova E, Kelemenova S, Ostatnikova D
Department of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Bratisl Lek Listy. 2009;110(12):765-72.
A substantial proportion of older men (ranging from 20% of 60-year-old to 50% of 80-year-old men) have total serum testosterone levels below the normal range for younger men (1). At the age of 75 years, mean plasma testosterone levels are only 65% of levels in young adults, whereas over 25% of these men have bioavailable testosterone levels below the lowest normal limit in young adults. The interindividual variations in the plasma levels are, however, very important and a quarter of men over 75 years old have still testosterone levels within the upper quartile of values in young men (2). Many symptoms associated with aging in men, including muscle atrophy and weakness, osteoporosis, reduced sexual functioning, and increased fat mass, are similar to changes associated with testosterone deficiency in young men. These similarities suggest that testosterone supplementation may prevent or reverse the effects of aging (3), improve the general well being, sexual characteristics and behaviour of elderly men (Fig. 4, Ref. 71).
相当一部分老年男性（60岁男性中占20%，80岁男性中占50%）的血清总睾酮水平低于年轻男性的正常范围（1）。在75岁时，血浆睾酮平均水平仅为年轻人的65%，而超过25%的此类男性其生物可利用睾酮水平低于年轻人的最低正常限度。然而，血浆水平的个体差异非常重要，四分之一的75岁以上男性的睾酮水平仍处于年轻男性值的上四分位数范围内（2）。男性与衰老相关的许多症状，包括肌肉萎缩和无力、骨质疏松、性功能减退以及脂肪量增加，与年轻男性睾酮缺乏相关的变化相似。这些相似之处表明，补充睾酮可能预防或逆转衰老的影响（3），改善老年男性的总体健康状况、性特征和行为（图4，参考文献71）。
