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营养疗法减轻血液透析患者炎症:事实还是虚构?

Nutritional therapy to attenuate inflammation in HD patients: fact or fiction?

作者信息

Sharma Amit, Gadepally Padma

机构信息

Boise Kidney and Hypertension Institute, Meridian, Idaho, USA.

出版信息

Nephrol News Issues. 2010 Jan;24(1):26-9.

PMID:20196499
Abstract

The hemodialysis (HD) patient is often marked by constant malnutrition, inflammation, and atherosclerosis, resulting in an increased risk of cardiovascular events and mortality. This chronic inflammatory state is often the result of increased oxidative stress. Nutritional supplementation may become an additional therapy to lower this inflammatory burden. By providing these patients with nutritional supplement and antioxidant therapies consisting of alpha-lipoic acid, cholecalciferol, ascorbic acid, and Gamma-Tocopherol, providers may reduce overall inflammation and improve HD outcomes in patients with end-stage renal disease.

摘要

血液透析(HD)患者常伴有持续的营养不良、炎症和动脉粥样硬化,导致心血管事件风险和死亡率增加。这种慢性炎症状态通常是氧化应激增加的结果。营养补充可能成为降低这种炎症负担的一种额外治疗方法。通过为这些患者提供由α-硫辛酸、胆钙化醇、抗坏血酸和γ-生育酚组成的营养补充剂和抗氧化疗法,医疗服务提供者可能会减轻总体炎症,并改善终末期肾病患者的血液透析效果。

相似文献

1
Nutritional therapy to attenuate inflammation in HD patients: fact or fiction?营养疗法减轻血液透析患者炎症:事实还是虚构?
Nephrol News Issues. 2010 Jan;24(1):26-9.
2
Overproduction of reactive oxygen species in end-stage renal disease patients: a potential component of hemodialysis-associated inflammation.终末期肾病患者活性氧的过度产生:血液透析相关炎症的一个潜在因素。
Hemodial Int. 2005 Jan;9(1):37-46. doi: 10.1111/j.1492-7535.2005.01116.x.
3
Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients.γ-生育酚和二十二碳六烯酸可减轻透析患者的炎症反应。
J Ren Nutr. 2007 Sep;17(5):296-304. doi: 10.1053/j.jrn.2007.05.011.
4
Inflammatory syndrome in patients on hemodialysis.血液透析患者的炎症综合征
J Am Soc Nephrol. 2006 Dec;17(12 Suppl 3):S274-80. doi: 10.1681/ASN.2006080926.
5
Association between novel indices of malnutrition-inflammation complex syndrome and cardiovascular disease in hemodialysis patients.血液透析患者中营养不良-炎症复合综合征新指标与心血管疾病的关联
Hemodial Int. 2005 Apr;9(2):159-68. doi: 10.1111/j.1492-7535.2005.01127.x.
6
Effects of unsaturated fat dietary supplements on blood lipids, and on markers of malnutrition and inflammation in hemodialysis patients.不饱和脂肪膳食补充剂对血液透析患者血脂、营养不良标志物及炎症的影响。
J Ren Nutr. 2009 Sep;19(5):401-11. doi: 10.1053/j.jrn.2009.04.006. Epub 2009 Jun 21.
7
Malnutrition in hemodialysis patients: what therapy?血液透析患者的营养不良:采用何种治疗方法?
Am J Kidney Dis. 2005 Sep;46(3):371-86. doi: 10.1053/j.ajkd.2005.05.031.
8
[Strong connection between malnutrition, inflammation and arteriosclerosis. Improved treatment of renal failure if underlying factors are attacked].[营养不良、炎症与动脉硬化之间存在紧密联系。若针对潜在因素进行治疗,可改善肾衰竭的治疗效果]
Lakartidningen. 1999 Oct 20;96(42):4538-42.
9
[Chronic inflammation and cardiovascular risk in hemodialysis].[血液透析中的慢性炎症与心血管风险]
G Ital Nefrol. 2003 Nov-Dec;20(6):631-40.
10
Association between serum albumin and mortality in dialysis patients is partly explained by inflammation, and not by malnutrition.透析患者血清白蛋白与死亡率之间的关联部分可由炎症解释,而非营养不良。
J Ren Nutr. 2009 Mar;19(2):127-35. doi: 10.1053/j.jrn.2008.08.003.

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Effects of zinc supplementation on plasma copper/zinc ratios, oxidative stress, and immunological status in hemodialysis patients.补锌对血液透析患者血浆铜/锌比值、氧化应激和免疫状态的影响。
Int J Med Sci. 2013;10(1):79-89. doi: 10.7150/ijms.5291. Epub 2012 Dec 22.