Max-Planck-Institute of Colloids and Interfaces, Department of Biomolecular Systems, Am Muhlenberg 1, 14476 Potsdam, Germany.
Org Lett. 2010 Apr 2;12(7):1624-7. doi: 10.1021/ol1003912.
Zwitterionic polysaccharides (ZPSs) are potent T-cell activators that naturally occur on the cell surface of bacteria and show potential as immunostimulatory agents. An unusual, yet important component of many ZPSs is 2-acetamido-4-amino-2,4,6-trideoxy-D-galactose (AAT). AAT building block 2 was prepared via a de novo synthesis from N-Cbz-L-threonine 5. Furthermore, building block 2 was used to synthesize disaccharide 15 that constitutes a fragment of zwitterionic polysaccharide A1 (PS A1) found in Bacteroides fragilis.
两性离子多糖（ZPSs）是天然存在于细菌表面的强效 T 细胞激活剂，具有作为免疫刺激剂的潜力。许多 ZPSs 的一个不寻常但重要的组成部分是 2-乙酰氨基-4-氨基-2,4,6-三脱氧-D-半乳糖（AAT）。AAT 砌块 2 是通过从头合成从 N-Cbz-L-苏氨酸 5 制备的。此外，砌块 2 用于合成二糖 15，该二糖构成了在脆弱拟杆菌中发现的两性离子多糖 A1（PS A1）的片段。
