Lim Johan, Kim Jayeon, Kim Byung Soo
Seoul National University.
Stat Appl Genet Mol Biol. 2010;9:Article 12. doi: 10.2202/1544-6115.1525. Epub 2010 Jan 26.
Klebanov et al. (2006) proposed a new type of stochastic dependence, Type A dependence, between gene expression levels. They estimated the abundance of Type A pairs by testing the correlation coefficients of gene pairs. We propose a new model, hidden regulator dependence, as an alternative to Type A dependence. We show that the correlation based procedure proposed by Klebanov et al. (2006) fails to differentiate hidden regulator dependence from Type A dependence, although their probabilistic structures are quite different.
克莱巴诺夫等人（2006年）提出了基因表达水平之间一种新型的随机依赖性，即A型依赖性。他们通过测试基因对的相关系数来估计A型对的丰度。我们提出一种新模型——隐藏调节因子依赖性，作为A型依赖性的替代方案。我们表明，克莱巴诺夫等人（2006年）提出的基于相关性的方法无法区分隐藏调节因子依赖性和A型依赖性，尽管它们的概率结构有很大不同。
