Collective Health Institute, Federal University of Mato Grosso, Av. Fernando Correia da Costa, s/n, Campus Universitário, 78060-900 Cuiabá, Mato Grosso, Brazil.
Vaccine. 2010 Apr 19;28(18):3127-33. doi: 10.1016/j.vaccine.2010.02.059. Epub 2010 Mar 1.
We estimated the sensitivity, i.e., the proportion of all cases of adverse events following immunization (AEFIs) reported to the Brazilian passive surveillance for adverse events following immunization (PSAEFI) with the diphtheria-tetanus-whole-cell pertussis-Haemophilus influenzae type b (DTwP/Hib) vaccine, as well as investigating factors associated with AEFIs reporting. During 2003-2004, 8303 AEFIs associated with DTwP-Hib were reported; hypotonic-hyporesponsive episodes (HHEs), fever and convulsions being the most common. Cure without sequel was achieved in 98.4% of the cases. The mean sensitivity of the PSAEFI was 22.3% and 31.6%, respectively, for HHE and convulsions, varying widely among states. Reporting rates correlated positively with the Human Development Index and coverage of adequate prenatal care, correlating negatively with infant mortality rates. Quality of life indicators and the degree of organization of health services are associated with greater PSAEFI sensitivity. In addition to consistently describing the principal AEFIs, PSAEFI showed the DTwP/Hib vaccine to be safe and allayed public fears related to its use.
我们评估了敏感性，即报告给巴西被动疫苗不良反应监测（PSAEFI）的所有疫苗不良反应（AEFI）的比例，这些 AEFI 与白喉-破伤风-全细胞百日咳-流感嗜血杆菌（DTwP/Hib）疫苗相关，同时调查了与 AEFI 报告相关的因素。2003-2004 年期间，报告了 8303 例与 DTwP-Hib 相关的 AEFI；低张性低反应性发作（HHE）、发热和惊厥是最常见的。98.4%的病例治愈后无后遗症。PSAEFI 的平均敏感性分别为 HHE 和惊厥的 22.3%和 31.6%，各州之间差异很大。报告率与人类发展指数和充分产前保健覆盖率呈正相关，与婴儿死亡率呈负相关。生活质量指标和卫生服务组织程度与更高的 PSAEFI 敏感性相关。PSAEFI 不仅一致描述了主要的 AEFI，还表明 DTwP/Hib 疫苗是安全的，缓解了公众对其使用的担忧。
