Charité University Medicine, Department of Pediatrics, 13553 Berlin, Germany.
Vaccine. 2010 Apr 26;28(19):3488-95. doi: 10.1016/j.vaccine.2010.02.053. Epub 2010 Mar 1.
Brighton Collaboration (BC) case definitions are independent from presumed causes or triggers, hence should be applicable in routine clinical settings.
255 cases with discharge diagnoses of aseptic meningitis (ASM; n=164), encephalitis (ENC; n=48), myelitis (MYE; n=8), ADEM (n=10), or bacterial meningitis (BM; n=59; control group) were tested against the BC case definitions ASM, ENC, MYE, and ADEM. Overall rates of agreement between BC criteria and discharge diagnoses were 70%, 78%, 97%, and 97% for ASM, ENC, MYE and ADEM, respectively.
BC case definitions are easily applicable in retrospective chart reviews allowing causality assessments with minimal selection bias.
布莱顿协作组织（BC）的病例定义与推测的病因或诱因无关，因此应该适用于常规临床环境。
对 255 例出院诊断为无菌性脑膜炎（ASM；n=164）、脑炎（ENC；n=48）、脊髓炎（MYE；n=8）、ADEM（n=10）或细菌性脑膜炎（BM；n=59；对照组）的病例进行了检测，以评估 BC 病例定义的 ASM、ENC、MYE 和 ADEM。BC 标准与出院诊断之间的总体一致性率分别为 70%、78%、97%和 97%，用于 ASM、ENC、MYE 和 ADEM。
BC 病例定义易于在回顾性图表审查中应用，允许进行因果关系评估，且选择偏倚最小。
