Laboratorio de Biomedicina Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Ciudad Universitaria, Chilpancingo, Guerrero, Mexico.
Leuk Res. 2010 Jun;34(6):728-32. doi: 10.1016/j.leukres.2009.11.027. Epub 2010 Mar 1.
This study evaluated the association of -401C/T and +452C/T polymorphisms of gamma-glutamyl hydrolase and the risk of relapse to acute lymphoblastic leukemia. Genotyping was performed in 70 children with acute lymphoblastic leukemia and 140 healthy children. An association between the -401C/T polymorphism and the risk of relapse was found (p=0.028), patients with the -401T/T genotype have 10.83 (95% CI 1.30-90.14) more chance of a relapse of leukemia. No association was found between the +452C/T polymorphism and the risk of relapse. Therefore, our investigation suggests that the -401C/T polymorphism in the gamma-glutamyl hydrolase may be a factor involved in the generation of relapse to disease in patients with ALL.
本研究评估了γ-谷氨酰水解酶的-401C/T 和 +452C/T 多态性与急性淋巴细胞白血病复发风险的关联。对 70 例急性淋巴细胞白血病患儿和 140 例健康儿童进行了基因分型。发现-401C/T 多态性与复发风险相关（p=0.028），-401T/T 基因型患者白血病复发的几率增加 10.83 倍（95%CI 1.30-90.14）。+452C/T 多态性与复发风险之间没有关联。因此，我们的研究表明，γ-谷氨酰水解酶的-401C/T 多态性可能是 ALL 患者疾病复发的一个相关因素。
