α疱疹病毒对细胞肌动蛋白和胆固醇的利用和滥用。

Alphaherpesvirus use and misuse of cellular actin and cholesterol.

机构信息

Department of Virology, Parasitology, and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.

出版信息

Vet Microbiol. 2010 Jun 16;143(1):2-7. doi: 10.1016/j.vetmic.2010.02.007. Epub 2010 Feb 11.

DOI:10.1016/j.vetmic.2010.02.007

PMID:20197219

Abstract

Two major structural elements of a cell are the cytoskeleton and the lipid membranes. Actin and cholesterol are key components of the cytoskeleton and membranes, respectively, and are involved in a plethora of different cellular processes. This review summarizes and discusses the interaction of alphaherpesviruses with actin and cholesterol during different stages of the replication cycle: virus entry, replication and assembly in the nucleus, and virus egress. Elucidating these interactions not only yields novel insights into the biology of these important pathogens, but may also shed new light on cell biological aspects of actin and cholesterol, and lead to novel avenues in the design of antiviral strategies.

摘要

细胞的两个主要结构元素是细胞骨架和脂膜。肌动蛋白和胆固醇分别是细胞骨架和膜的关键组成部分，参与了许多不同的细胞过程。本综述总结并讨论了α疱疹病毒在复制周期的不同阶段与肌动蛋白和胆固醇的相互作用：病毒进入、核内复制和组装，以及病毒出芽。阐明这些相互作用不仅为这些重要病原体的生物学提供了新的见解，而且可能为肌动蛋白和胆固醇的细胞生物学方面提供新的线索，并为抗病毒策略的设计开辟新的途径。