Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.
Gynecol Obstet Invest. 2010;70(1):60-3. doi: 10.1159/000289178. Epub 2010 Feb 27.
We wished to investigate the correlation between a new Down screening marker ADAM12 (a disintegrin and metalloproteinase-12) and pregnancy-associated plasma protein-A (PAPP-A) and free beta-human chorionic gonadotropin (fbeta-hCG) during the first trimester of pregnancy.
ADAM12, PAPP-A and fbeta-hCG were measured in 225 serum samples of randomly chosen pregnancies with completely normal outcome. The samples were taken between pregnancy weeks 9+0 and 12+6.
The ADAM12 levels tended to increase with advanced gestational age and the highest levels were detected at pregnancy week 12. The ADAM12 levels correlated with PAPP-A levels. After weight correction and logarithmic transformation the multiples of median (MoM) of ADAM12 still correlated with the MoMs of PAPP-A and also with the MoMs of fbeta-hCG. Smokers had lower ADAM12 levels than non-smokers.
The secretion of ADAM12 seems to resemble the secretion of PAPP-A in the end of the first trimester. Accordingly ADAM12 appears not to be a separate marker independent of PAPP-A. It remains to be assessed whether adding ADAM12 in Down screening risk calculation will reduce the false positive rate during the first trimester of pregnancy.
我们希望研究新的唐氏综合征筛查标志物 ADAM12（解整合素金属蛋白酶 12）与妊娠相关血浆蛋白-A（PAPP-A）和游离β-人绒毛膜促性腺激素（fβ-hCG）在妊娠早期之间的相关性。
在 225 例完全正常妊娠的随机选择的血清样本中测量 ADAM12、PAPP-A 和 fβ-hCG。这些样本取自妊娠 9+0 至 12+6 周之间。
ADAM12 水平随着孕龄的增加而趋于升高，在妊娠 12 周时达到最高水平。ADAM12 水平与 PAPP-A 水平相关。经体重校正和对数转换后，ADAM12 的倍数中位数（MoM）仍与 PAPP-A 的 MoM 以及 fβ-hCG 的 MoM 相关。吸烟者的 ADAM12 水平低于不吸烟者。
ADAM12 的分泌似乎类似于妊娠早期 PAPP-A 的分泌。因此，ADAM12 似乎不是一种独立于 PAPP-A 的单独标志物。尚需评估在唐氏综合征筛查风险计算中添加 ADAM12 是否会降低妊娠早期的假阳性率。
