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以色列北部首次原发性脑出血的种族差异。

Ethnic disparities in first primary intracerebral hemorrhage in northern Israel.

机构信息

Departments of Neurology and Neurosurgery, Rambam Health Care Campus, Technion Faculty of Medicine, Haifa, Israel.

出版信息

Neuroepidemiology. 2010;34(4):208-13. doi: 10.1159/000289352. Epub 2010 Mar 3.

Abstract

BACKGROUND

Ethnic differences among first primary intracerebral hemorrhage (PICH) patients in an Israeli biethnic population have not yet been studied.

PATIENTS AND METHODS

We included in the study 546 patients (counting warfarin-related hemorrhages) hospitalized during the period from December 1999 through June 2008.

RESULTS

The mean age was 71.1 +/- 14 years for the Jewish patients and 63.3 +/- 13.9 years for the Arab patients (p < 0.0001). Diabetes and smoking were significantly more frequent among the Arab patients. No difference was found between groups by location, extent, or ventricular involvement of PICH. Although the in-hospital mortality rate was significantly higher among the Jewish patients, adjustment of the model combining multiple risk factors for PICH eliminated this difference.

CONCLUSIONS

There are differences in the demographic and vascular risk factor profiles between Arab and Jewish PICH patients, with the Arabs found to be younger and to suffer more from diabetes. The location and extent of intracerebral hemorrhage as well as functional outcome were similar between the two groups. The apparent higher in-hospital mortality in the group of Jewish patients was eliminated when the influence of multiple covariates other than ethnicity, main vascular risk factors and international normalized ratio level were taken into consideration.

摘要

背景

在一个以色列的多民族人群中,首次原发性脑出血(PICH)患者之间的种族差异尚未得到研究。

患者和方法

我们纳入了 546 名患者(包括华法林相关出血),这些患者于 1999 年 12 月至 2008 年 6 月期间住院。

结果

犹太患者的平均年龄为 71.1±14 岁,阿拉伯患者的平均年龄为 63.3±13.9 岁(p<0.0001)。糖尿病和吸烟在阿拉伯患者中更为常见。两组患者的 PICH 部位、程度或脑室受累无差异。尽管犹太患者的住院死亡率显著更高,但对 PICH 的多种危险因素进行综合调整后,这种差异消失了。

结论

阿拉伯和犹太 PICH 患者在人口统计学和血管危险因素特征方面存在差异,阿拉伯患者更年轻,更易患糖尿病。两组患者的脑出血部位和程度以及功能预后相似。当考虑到除种族、主要血管危险因素和国际标准化比值水平以外的多种混杂因素的影响时,犹太患者组中明显更高的住院死亡率被消除了。

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