Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan, P.R. China.
Int J Mol Med. 2010 Apr;25(4):531-6.
Microglia, the resident immune cells of the central nervous system (CNS), are activated by various stimuli. Resting microglia are the basis of normal neurogenesis, while activated microglia may inhibit neurogenesis through the production of pro-inflammatory mediators and cytokines. Recent research suggests that microglia are activated by irradiation. This may play a role in radiation-induced brain injury (RIBI). DNA double-strand breaks (DSBs), the most deleterious form of DNA damage after ionizing radiation, may rapidly trigger the activation of the NF-kappaB pathway via p53-induced protein leading to the release of pro-inflammatory mediators and cytokines. Thus, a negative regulator of the NF-kappaB pathway that inhibits radiation-induced microglia activation could be used to treat RIBI. Corilagin, a member of the tannin family, inhibits NF-kappaB pathway activation. In the present study, we examined the inhibitory effects of corilagin on radiation-induced microglia activation using a variety of techniques. Our data suggest that corilagin inhibits radiation-induced microglia activation via suppression of the NF-kappaB pathway and the compound is a potential treatment for RIBI.
小胶质细胞是中枢神经系统（CNS）的固有免疫细胞，可被各种刺激激活。静息小胶质细胞是正常神经发生的基础，而激活的小胶质细胞可能通过产生促炎介质和细胞因子来抑制神经发生。最近的研究表明，小胶质细胞可被辐照激活。这可能在放射性脑损伤（RIBI）中起作用。DNA 双链断裂（DSBs）是电离辐射后最具细胞毒性的 DNA 损伤形式，可能通过 p53 诱导蛋白迅速触发 NF-κB 途径的激活，导致促炎介质和细胞因子的释放。因此，抑制 NF-κB 途径激活的小胶质细胞的负调节剂可用于治疗 RIBI。鞣花酸是单宁家族的一员，可抑制 NF-κB 途径的激活。在本研究中，我们使用多种技术研究了鞣花酸对辐射诱导的小胶质细胞激活的抑制作用。我们的数据表明，鞣花酸通过抑制 NF-κB 途径抑制辐射诱导的小胶质细胞激活，该化合物可能是 RIBI 的一种潜在治疗方法。
