Department of Biochemistry, Faculty of Medicine of Sousse, Sousse, Tunisia.
Neurol Sci. 2010 Dec;31(6):687-91. doi: 10.1007/s10072-010-0234-4. Epub 2010 Mar 3.
Alzheimer's disease (AD) is the leading cause of dementia. Several studies indicate a possible relationship between different genes and Alzheimer's disease. To further investigate, we have analyzed the association between the bleomycin hydrolase (BLMH) and apolipoprotein E (ApoE) polymorphisms in 93 AD patients and age- and sex-matched 113 controls from the Tunisian population. The frequency of ApoE epsilon 4 allele was found to differ significantly in AD patients compared to the control [29.5% vs. 8.8 (χ (2) = 26, df = 1, p < 0.001)] leading to an increased risk of AD in subjects with this allele (OR = 3.29, 95% CI = 1.7-6.5; p = 0.001]. This risk was found to decrease from OR = 8.4, CI = 3.3-23; p < 0.001 in subjects less than 75 years old to OR = 1.2, CI = 1.031-14; p = 0.0297 in subjects 75 years and older. No association was observed between carrying the BLMH-G genotype and AD in ε4 negative or positive subjects.
阿尔茨海默病（AD）是痴呆症的主要病因。有几项研究表明，不同基因与阿尔茨海默病之间可能存在关联。为了进一步研究，我们分析了来自突尼斯人群的 93 名 AD 患者和年龄、性别匹配的 113 名对照者之间的博来霉素水解酶（BLMH）和载脂蛋白 E（ApoE）多态性之间的关联。与对照组相比，AD 患者的 ApoE ε4 等位基因频率差异有统计学意义[29.5%对 8.8（χ²=26，df=1，p<0.001）]，导致携带该等位基因的个体患 AD 的风险增加（OR=3.29，95%CI=1.7-6.5；p=0.001]。在年龄小于 75 岁的患者中，这种风险从 OR=8.4，CI=3.3-23；p<0.001 降低到 OR=1.2，CI=1.031-14；p=0.0297 在 75 岁及以上的患者中。在 ε4 阴性或阳性的患者中，携带 BLMH-G 基因型与 AD 之间没有关联。
