伊朗东南部对氧磷酶-1 Q192R多态性与类风湿关节炎之间无关联。
Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran.
作者信息
Hashemi M, Moazeni-Roodi A K, Fazaeli A, Sandoughi M, Bardestani G R, Kordi-Tamandani D M, Ghavami S
机构信息
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
出版信息
Genet Mol Res. 2010 Feb 23;9(1):333-9. doi: 10.4238/vol9-1gmr728.
Decreased paraoxonase-1 (PON1) activity has been associated with rheumatoid arthritis. There are two polymorphisms in serum PON1; one differs in the amino acid at position 192 (Q192R) and the other one differs at position 55 (L55M). We looked for a possible association between Q192R polymorphism and rheumatoid arthritis. The Q192R polymorphism in 88 rheumatoid arthritis patients and 78 healthy subjects was determined using tetra amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and PCR-restriction fragment length polymorphism (RFLP) methods. We found no significant differences between rheumatoid arthritis patients and control subjects regarding PON1 Q192R polymorphism. PON1 Q192R polymorphism was not found to be correlated with increased risk for rheumatoid arthritis in this Iranian population.
对氧磷酶-1（PON1）活性降低与类风湿性关节炎有关。血清PON1存在两种多态性；一种在第192位氨基酸处不同（Q192R），另一种在第55位不同（L55M）。我们探究了Q192R多态性与类风湿性关节炎之间可能存在的关联。采用四重扩增阻滞突变系统-聚合酶链反应（ARMS-PCR）和PCR-限制性片段长度多态性（RFLP）方法，对88例类风湿性关节炎患者和78名健康受试者的Q192R多态性进行了测定。我们发现，在PON1 Q192R多态性方面，类风湿性关节炎患者与对照受试者之间无显著差异。在这一伊朗人群中，未发现PON1 Q192R多态性与类风湿性关节炎风险增加相关。
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