原发性胆汁性胆管炎相关自身抗体在原发性硬化性胆管炎患者中的诊断价值
Lack of association between paraoxonase 1 Q192R polymorphism and multiple sclerosis in relapse phase: A case-control study.
机构信息
Neurology Department, Zahedan University of Medical Sciences, Zahedan, Iran.
出版信息
Clin Biochem. 2011 Jul;44(10-11):795-8. doi: 10.1016/j.clinbiochem.2011.04.010. Epub 2011 Apr 22.
OBJECTIVES
The aim of this study was to estimate the serum activity of paraoxonase 1(PON1) and assess the distribution of PON1 polymorphisms in MS patients in the relapse phase.
DESIGN AND METHODS
PON1 and arylesterase (ARE) serum activities were measured in two equal groups (each group 63 cases) of relapsing-remitting MS patients and healthy individuals.
RESULTS
Mean values for serum PON1 and ARE activities were 90.3±63.4 and 182.1±128.7IU/L for patients and 99.9±73.3 and 190.8±150.3IU/L for controls. Those values were not statistically significant (p=0.242 and p=0.378), respectively. Comparing genotype distributions and allele frequencies in both groups for PON1 Q192R and PON L55M polymorphisms did not show any statistical difference.
CONCLUSION
In a selected group of MS patients in relapsing phase no statistically significant difference in PON1 and ARE activities was detected but the mean values for the serum enzyme activities were lower in MS patients.
目的
本研究旨在评估处于复发期的多发性硬化症（MS）患者血清对氧磷酶 1（PON1）的活性，并评估 PON1 多态性的分布情况。
设计与方法
将复发缓解型 MS 患者（每组 63 例）和健康个体分为两组，分别测量两组人群血清 PON1 和芳香酯酶（ARE）的活性。
结果
患者血清 PON1 和 ARE 活性的平均值分别为 90.3±63.4IU/L 和 182.1±128.7IU/L，对照组的平均值分别为 99.9±73.3IU/L 和 190.8±150.3IU/L。这些值无统计学差异（p=0.242 和 p=0.378）。比较两组人群 PON1 Q192R 和 PON L55M 多态性的基因型分布和等位基因频率，未显示出任何统计学差异。
结论
在选择的处于复发期的 MS 患者亚组中，未发现 PON1 和 ARE 活性有统计学显著差异，但 MS 患者的血清酶活性平均值较低。
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