Carretié Luis, López-Martin Sara, Albert Jacobo
UAM. Universidad Autonoma de Madrid. Facultad de Psicologia, 28049 Madrid, Espana.
Rev Neurol. 2010;50(4):245-52.
This review presents data showing the key role of ventromedial prefrontal cortex (here defined as an extensive area that includes ventral and medial prefrontal cortices) in the neural circuitry in charge of responding to negative events (i.e., dangerous, painful or disgusting).
Ventromedial prefrontal cortex has rapid access to visual information and, in consequence, is able to react to negative visual events at approximately 100-150 ms from the stimulus onset. Its response to this type of stimulation, even when it is unconsciously perceived, is more intense than to non-negative stimuli. The main connections of this prefrontal area with sensorial structures (both up, in order to get incoming sensory information, and down, modulating the activity of these areas), with regions in charge of cognitive processes relevant to take a decision on how to cope with the negative stimulus (e.g., memory, action planning), and with areas in charge of autonomic and motor execution, are described.
An integrative schema of the role of ventromedial prefrontal cortex in the response to negative events is provided.
本综述展示的数据表明，腹内侧前额叶皮质（此处定义为一个广泛区域，包括腹侧和内侧前额叶皮质）在负责对负面事件（即危险、疼痛或恶心的事件）做出反应的神经回路中起着关键作用。
腹内侧前额叶皮质能够快速获取视觉信息，因此能够在刺激开始后约100 - 150毫秒对负面视觉事件做出反应。即使在无意识感知的情况下，它对这类刺激的反应也比对非负面刺激的反应更强烈。本文描述了该前额叶区域与感觉结构（向上以获取传入的感觉信息，向下调节这些区域的活动）、负责与应对负面刺激的决策相关的认知过程的区域（如记忆、行动规划）以及负责自主和运动执行的区域之间的主要连接。
提供了腹内侧前额叶皮质在对负面事件反应中的作用的综合模式。
