Imai S, Otorii T, Takeda K, Katano Y, Nakagawa Y
Recent Adv Stud Cardiac Struct Metab. 1976;11:335-41.
With the use of an organ redoximeter, the effects of noradrenaline, adrenaline, isoproterenol, and phenylephrine on the oxidation-reduction state of the myocardial pyridine nucleotides were studied in the canine heart-lung preparation supported by a donor. Noradrenaline and adrenaline produced an initial, transient improvement, and phenylephrine a sustained improvement, of the redox state, while isoproterenol produced a depression. Pretreatment of the preparation with adrenergic alpha-blockers resulted in an abolishment of the improvement by noradrenaline, adrenaline, and phenylephrine, while the depression by isoproterenol remained unchanged. Whereas noradrenaline and adrenaline produced a sustained improvement after an adrenergic beta-blocker, propranolol, the effect of isoproterenol was abolished. These findings suggest that sympathomimetic amines can produce an improvement of the myocardial energy metabolism through activation of the adrenergic alpha-receptor. The depression of the myocardial oxidation-reduction state was taken to represent an acceleration of glycolysis.
利用器官氧化还原计，在由供体支持的犬心肺制备物中，研究了去甲肾上腺素、肾上腺素、异丙肾上腺素和去氧肾上腺素对心肌吡啶核苷酸氧化还原状态的影响。去甲肾上腺素和肾上腺素使氧化还原状态产生初始的、短暂的改善，去氧肾上腺素使其产生持续的改善，而异丙肾上腺素则使其降低。用肾上腺素能α受体阻滞剂预处理该制备物，可消除去甲肾上腺素、肾上腺素和去氧肾上腺素引起的改善，而异丙肾上腺素引起的降低则保持不变。虽然在使用肾上腺素能β受体阻滞剂普萘洛尔后，去甲肾上腺素和肾上腺素产生了持续的改善，但异丙肾上腺素的作用被消除。这些发现表明，拟交感胺可通过激活肾上腺素能α受体来改善心肌能量代谢。心肌氧化还原状态的降低被认为代表糖酵解加速。
