Mustafa Kemal University, Department of Nephrology, Hatay, Turkey.
Ren Fail. 2010 Jan;32(2):198-202. doi: 10.3109/08860220903491232.
The prevalence and risk factors of cardiovascular disease (CVD) are increasing in end stage renal disease (ESRD) patients. In this study, we sought to research the relationship between the insulin resistance, which is one of the risk factors for CVD, and the inflammation markers, especially C-reactive protein, fibrinogen, uric acid, and homocysteine levels in our patients who were recently diagnosed with ESRD and started hemodialysis.
64 HOMA-IR-positive and 114 HOMA-IR-negative patients were enrolled in this study. Blood samples were obtained from the patients for fasting plasma glucose, insulin, CRP, fibrinogen, uric acid, total homocysteine, urea, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, total protein, and albumin analysis after physical examinations and anamnesis were completed.
Fibrinogen and CRP levels of HOMA-IR-positive HD patients were significantly increased compared to non-insulin resistants. Furthermore, there is significant positive relationship between insulin resistance and serum CRP and fibrinogen levels in these HOMA-IR-positive HD patients (r = 0.258, p < 0.001).
We found out that the fibrinogen and CRP levels are significantly high in HOMA-IR positive HD patients, according to determine the risk ratio for coronary artery disease in HD patients, and think that an assessment of insulin resistance is necessary.
心血管疾病（CVD）在终末期肾病（ESRD）患者中的患病率和风险因素正在增加。在这项研究中，我们试图研究胰岛素抵抗（CVD 的一个风险因素）与炎症标志物（尤其是 C 反应蛋白、纤维蛋白原、尿酸和同型半胱氨酸水平）之间的关系，这些标志物在最近被诊断为 ESRD 并开始血液透析的患者中。
本研究纳入了 64 名 HOMA-IR 阳性和 114 名 HOMA-IR 阴性患者。对患者进行体检和病史询问后，采集空腹血糖、胰岛素、CRP、纤维蛋白原、尿酸、总同型半胱氨酸、尿素、总胆固醇、HDL-胆固醇、LDL-胆固醇、甘油三酯、总蛋白和白蛋白分析的血样。
与非胰岛素抵抗者相比，HOMA-IR 阳性 HD 患者的纤维蛋白原和 CRP 水平显着升高。此外，这些 HOMA-IR 阳性 HD 患者的胰岛素抵抗与血清 CRP 和纤维蛋白原水平之间存在显着正相关（r = 0.258，p <0.001）。
我们发现 HOMA-IR 阳性 HD 患者的纤维蛋白原和 CRP 水平显着升高，根据确定 HD 患者患冠状动脉疾病的风险比，我们认为有必要评估胰岛素抵抗。
