Department of Neurology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
Int J Neurosci. 2010 Feb;120(2):115-9. doi: 10.3109/00207450903389131.
Myasthenia gravis (MG) is a disorder of neuromuscular junction associated with presence of antibodies against nicotinic acetylcholine receptors (nAChRs). Here, we compared the clinical and serological profile of seropositive myasthenia gravis (SPMG) and seronegative myasthenia gravis (SNMG) patients. Anti-AChR antibody was measured using radio receptor immunoassay and correlated with clinical phenotype in 250 MG patients over 2004 and 2006. Out of 250 MG patients, 161 (64.4%) were males (male:female = 1.8:1). SNMG patients formed 40% (n = 101) of our MG patients which is much higher as compared to Caucasian and Oriental population (15%-20%). The median age of disease onset in SPMG was significantly higher than SNMG patients (43 years; range 8-74 vs. 35 years; range 4-72, p = .022). A bimodal peak of age of disease onset in both genders was observed (first peak in second-third decades and second one in fifth-sixth decades). Among the MG patients with late-onset of disease, male were significantly higher compared to Caucasian and Oriental MG population (p = .047). MG patients with thymoma were significantly older and consisted of higher percent of males. Bulbar symptoms and severe grade (IIB+ III+ IV) at disease onset were more frequent in SPMG than SNMG patients.
重症肌无力（MG）是一种神经肌肉接头疾病，与烟碱型乙酰胆碱受体（nAChR）抗体的存在有关。在这里，我们比较了阳性重症肌无力（SPMG）和阴性重症肌无力（SNMG）患者的临床和血清学特征。使用放射受体免疫测定法测量抗 AChR 抗体，并在 2004 年至 2006 年间对 250 名 MG 患者的临床表型进行了相关性分析。在 250 名 MG 患者中，161 名（64.4%）为男性（男性：女性=1.8：1）。SNMG 患者占我们 MG 患者的 40%（n=101），这比高加索人和东方人群高得多（15%-20%）。SPMG 患者的疾病发病中位年龄明显高于 SNMG 患者（43 岁；范围 8-74 岁与 35 岁；范围 4-72，p=0.022）。在两性中均观察到疾病发病年龄的双峰模式（第一个高峰在二十至三十岁，第二个高峰在五十至六十岁）。在疾病发病较晚的 MG 患者中，男性明显高于高加索人和东方 MG 人群（p=0.047）。有胸腺瘤的 MG 患者明显年龄较大，且男性比例较高。与 SNMG 患者相比，SPMG 患者在疾病发病时出现球部症状和严重程度（IIB+III+IV）的频率更高。
