Department of Obstetrics and Gynecology, University Central Hospital, Helsinki, Finland.
Acta Obstet Gynecol Scand. 2010 Jul;89(7):916-23. doi: 10.3109/00016341003605685.
Placental abruption is an important cause of preterm birth, and perinatal morbidity and mortality. Although more common with male fetuses, outcomes have not been evaluated by sex. Our aim was to find out whether short-term morbidity differs by infant sex in cases with placental abruption and in controls.
Register-based case-control study.
National Hospital Discharge Register and Medical Birth Register data 1987-2005.
The study population consisted of 4,081 women with placental abruption and singleton infant. Three control women without placental abruption were selected for each case matched by maternal age, parity, year of birth, and hospital district. A total of 3,688 cases and 12,695 controls had liveborn infants.
Data on pregnancy, delivery, and perinatal outcomes were collected.
Placental abruption.
The sex ratio (proportion of male) of cases was 0.548 and of controls 0.516 (p = 0.001). Compared with females, male fetuses in the placental abruption group were born earlier (p = 0.018). Compared with controls, cases with placental abruption were born earlier (p < 0.001), had lower birthweight (p < 0.001), were more often growth restricted (p < 0.001), had lower Apgar scores (p < 0.001) and pH (p < 0.001). Newborn cases needed special care, respirator treatment, antimicrobial and phototherapy more often (p < 0.001) than controls. There was no difference in perinatal outcomes between female and male infants in the placental abruption group.
Placental abruption occurred earlier in pregnancy with male fetal sex but otherwise the outcomes were similar. Compared with controls newborns in the placental abruption group had a worse outcome.
胎盘早剥是早产和围产儿发病率和死亡率的重要原因。尽管男性胎儿更为常见，但尚未根据性别评估结局。我们的目的是确定胎盘早剥病例和对照组中，男婴和女婴的短期发病率是否存在差异。
基于登记的病例对照研究。
1987 年至 2005 年国家住院登记处和医疗出生登记处的数据。
研究人群包括 4081 名胎盘早剥和单胎婴儿的女性。每例胎盘早剥病例选择 3 名无胎盘早剥的对照女性，按母亲年龄、产次、出生年份和医院区进行匹配。共有 3688 例病例和 12695 例对照分娩出活产婴儿。
收集妊娠、分娩和围产儿结局数据。
胎盘早剥。
病例组的性别比（男婴比例）为 0.548，对照组为 0.516（p=0.001）。与女性相比，胎盘早剥组的男婴出生更早（p=0.018）。与对照组相比，胎盘早剥病例的分娩更早（p<0.001），出生体重更低（p<0.001），生长受限更为常见（p<0.001），Apgar 评分更低（p<0.001），pH 值更低（p<0.001）。新生儿病例需要特殊护理、呼吸机治疗、抗生素和光疗的比例更高（p<0.001）。胎盘早剥组中女性和男性婴儿的围产儿结局没有差异。
胎盘早剥发生在男性胎儿时更早，但其他方面结局相似。与对照组相比，胎盘早剥组的新生儿结局更差。
