衰竭犬心脏中心肌线粒体的研究：电子自旋共振（ESR）光谱法研究
Studies on myocardial mitochondria in failing dog hearts: studies by electron spin resonance (ESR) spectrometry.
作者信息
Suzuki Y, Yamazaki N, Ogawa K, Mizutani K, Kakizawa N
出版信息
Recent Adv Stud Cardiac Struct Metab. 1976;11:599-603.
The formation of free radicals, which was represented by the concentration of free radicals in state 4 respiration, and the respiratory control ratio were studied in the myocardial mitochondria isolated from dog hearts that were failing due to aortic constriction. Both formation and respiratory control ratio were lowered, compared to each control value, in acute and chronic heart failure. A positive correlation was recognized between free radicals in state 4 respiration and respiratory control ratio. From these results it was concluded that there was uncoupling of oxidative phosphorylation in the mitochondria isolated from failing dog hearts. Measurement of free radicals in state 4 respiration, as well as respiratory control ratio, is a useful method for evaluation of the function of oxidative phosphorylation.
以状态4呼吸中自由基浓度为代表的自由基形成以及呼吸控制率，在从因主动脉缩窄而衰竭的犬心脏分离出的心肌线粒体中进行了研究。与每个对照值相比，急性和慢性心力衰竭时自由基形成和呼吸控制率均降低。状态4呼吸中的自由基与呼吸控制率之间存在正相关。从这些结果得出结论，在从衰竭犬心脏分离出的线粒体中存在氧化磷酸化的解偶联。测量状态4呼吸中的自由基以及呼吸控制率，是评估氧化磷酸化功能的一种有用方法。
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