急性游离脂肪酸动员对缺血性心脏的致心律失常作用。

Arrhythmogenic effects of acute free fatty acid mobilization on ischemic heart.

作者信息

Yamazaki N, Suzuki Y, Kamikawa T, Ogawa K, Mizutani K, Kakizawa N, Yamamoto M

出版信息

Recent Adv Stud Cardiac Struct Metab. 1976;12:271-7.

PMID:201997

Abstract

The mechanism of action of the acute abnormal rise of plasma free fatty acids (FFA) in the provocation of arrhythmia in ischemic heart was studied by means of electron spin resonance (ESR) spectrometer. A sudden and abnormal rise of plasma FFA caused a significant fall of the respiratory control index (RCI) of the amount of free radical myocardial mitochondria in state 4 respiration. Based on these findings, a sudden and abnormal rise of plasma FFA seems to further facilitate the uncoupling of oxidative phosphorylation in the myocardial mitochondria of the ischemic portion of the heart. These observations indicate that it may play an important role in the provocation of arrhythmia by high plasma FFA on the ischemic heart. Nicomol (2,2,6,6,-tetrakis (nicotinoyloxymethyl) cyclohexanol), an inhibitor for the rapid rise of plasma FFA, was effective in the treatment and prevention of arrhythmia in ischemic heart disease and diabetes mellitus.

摘要

利用电子自旋共振（ESR）光谱仪研究了缺血性心脏病中血浆游离脂肪酸（FFA）急性异常升高诱发心律失常的作用机制。血浆FFA的突然异常升高导致状态4呼吸中自由基心肌线粒体数量的呼吸控制指数（RCI）显著下降。基于这些发现，血浆FFA的突然异常升高似乎进一步促进了心脏缺血部位心肌线粒体氧化磷酸化的解偶联。这些观察结果表明，血浆FFA升高可能在缺血性心脏诱发心律失常中起重要作用。尼可莫尔（2,2,6,6 - 四（烟酰氧基甲基）环己醇），一种抑制血浆FFA快速升高的药物，对缺血性心脏病和糖尿病心律失常的治疗和预防有效。