Latham Gregory J, Greenberg Robert S
Department of Anesthesiology and Pain Medicine, Seattle Children's Hospital, University of Washington School of Medicine, 4800 Sand Point Way N.E., Seattle, WA 98105, USA.
Paediatr Anaesth. 2010 May;20(5):396-420. doi: 10.1111/j.1460-9592.2010.03260.x. Epub 2010 Feb 18.
One of the prices paid for chemo- and radiotherapy of cancer in children is damage to the vulnerable and developing healthy tissues of the body. Such damage can exist clinically or subclinically and can become apparent during active antineoplastic treatment or during remission decades later. Furthermore, effects of the tumor itself can significantly impact the physiologic state of the child. The anesthesiologist who cares for children with cancer or for survivors of childhood cancer should understand what effects cancer and its therapy can have on various organ systems. In part two of this three-part review, we review the anesthetic issues associated with childhood cancer. Specifically, this review presents a systems-based approach to the impact from both tumor and its treatment in children, followed by a discussion of the relevant anesthetic considerations.
儿童癌症化疗和放疗所付出的代价之一是对身体脆弱且正在发育的健康组织造成损害。这种损害可能在临床上或亚临床状态下存在，并可能在积极的抗肿瘤治疗期间或数十年后的缓解期显现出来。此外，肿瘤本身的影响会显著影响儿童的生理状态。照料患癌儿童或儿童癌症幸存者的麻醉医生应了解癌症及其治疗方法会对各个器官系统产生何种影响。在这篇分三部分的综述的第二部分中，我们回顾了与儿童癌症相关的麻醉问题。具体而言，本综述提出了一种基于系统的方法，来探讨肿瘤及其治疗方法对儿童的影响，随后讨论了相关的麻醉注意事项。
