Department of Ophthalmology, Taipei Medical University Hospital, 252 Wu-Hsing Street, Taipei 110, Taiwan.
Neurology. 2010 Mar 9;74(10):792-7. doi: 10.1212/WNL.0b013e3181d31e5c. Epub 2010 Mar 3.
To investigate the risk of stroke development following a diagnosis of herpes zoster ophthalmicus (HZO).
Data were retrospectively collected from the Taiwan National Health Insurance Research Database. The study cohort comprised all patients with a diagnosis of HZO (ICD-9-CM code 053.2) in 2003 and 2004 (n = 658). The comparison cohort was comprised of randomly selected patients (3 for every HZO patient, n = 1974) matched with the study group in terms of age and gender. Patients were tracked from their index visits for 1 year. The Kaplan-Meier method was utilized to compute the 1-year stroke-free survival rate. Cox proportional hazard regressions were carried out to compute the adjusted 1-year stroke-free survival rate after adjusting for possible confounding factors.
Stroke developed in 8.1% of patients with HZO and 1.7% of patients in the comparison cohort during the 1-year follow-up period. HZO patients had significantly lower 1-year stroke-free survival rates than patients in the comparison cohort. After adjusting for patients' demographic characteristics, selected comorbidities, and medication habits, HZO patients were found to have a 4.52-fold (95% confidence interval 2.45-8.33) higher risk of stroke than the matched comparison cohort. There was no significant difference in the rate of stroke development between patients who had received systemic antiviral treatment and those who had not.
Herpes zoster ophthalmicus may represent a marker of increased risk of stroke development during the 1-year follow-up period.
研究带状疱疹性眼病（HZO）诊断后发生中风的风险。
数据来自台湾全民健康保险研究数据库的回顾性收集。研究队列包括 2003 年和 2004 年诊断为 HZO（ICD-9-CM 代码 053.2）的所有患者（n=658）。对照组由与研究组年龄和性别相匹配的随机选择的患者（每例 HZO 患者 3 例，n=1974）组成。患者从就诊日起随访 1 年。采用 Kaplan-Meier 法计算 1 年无中风生存率。采用 Cox 比例风险回归分析调整可能的混杂因素后计算调整后的 1 年无中风生存率。
在 1 年的随访期间，8.1%的 HZO 患者和 1.7%的对照组患者发生中风。HZO 患者的 1 年无中风生存率明显低于对照组患者。调整患者的人口统计学特征、选定的合并症和用药习惯后，HZO 患者发生中风的风险比匹配的对照组高 4.52 倍（95%置信区间 2.45-8.33）。接受全身抗病毒治疗和未接受治疗的患者发生中风的比率无显著差异。
带状疱疹性眼病可能是 1 年内发生中风风险增加的标志物。
