Wills Eye Institute, Cornea Service, Department of Ophthalmology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Ophthalmology. 2011 Nov;118(11):2242-50. doi: 10.1016/j.ophtha.2011.04.002. Epub 2011 Jul 23.
To study the clinical course of herpes zoster ophthalmicus (HZO) and to compare the demographics, treatments, and outcomes in patients aged <60 years versus patients aged ≥60 years at the time of diagnosis.
Retrospective chart review of all 112 patients presenting for management of HZO from January 1, 2008 to December 31, 2008.
A total of 112 patients (58 aged <60 years and 54 aged >60 years) at the time of HZO onset.
Anterior segment complications, treatments, and surgical procedures were documented at 3 months, 6 months, and 1 year, and then annually for the remainder of the follow-up period.
Intraocular pressure, inflammation, steroid use, surgical procedures, anterior segment complications, post-herpetic neuralgia, and delayed herpes zoster pseudodendrites.
Equal numbers of patients were affected with HZO in the younger and older age groups (51.8%, n = 58 vs. 48.2%, n = 54, respectively, P = 0.69). The most common decade of HZO onset was between 50 and 59 years. Younger patients were more likely to be healthy compared with older patients (P = 0.05). Delayed herpes zoster pseudodendrites were more common in the younger patients (36.7% vs. 16.7%, P = 0.03). The mean number of flares per patient-years was significantly higher in the younger patients (z test, P = 0.024). Post-herpetic neuralgia, neurotrophic keratopathy, and secondary infectious keratitis were more frequent in the older patients (P = 0.05). Prevalence of corneal perforation, corneal thinning, cataract formation, and glaucoma was similar between the 2 groups. Most patients in both groups (84.2% of younger patients and 89.5% of older patients) were taking topical steroids 3 years after referral for HZO.
Herpes zoster ophthalmicus affects individuals aged younger than and older than 60 years in similar numbers, with the most common decade of onset between age 50 and 59 years. Younger patients had more episodes of delayed pseudodendritiform keratitis and flares of inflammation compared with older patients, who had more problems related to neurotrophic keratopathy.
FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
研究带状疱疹性眼病（HZO）的临床病程，并比较<60 岁和≥60 岁患者在诊断时的人口统计学、治疗和结局。
对 2008 年 1 月 1 日至 2008 年 12 月 31 日期间因 HZO 就诊的 112 名患者的所有病历进行回顾性图表分析。
共 112 名患者（58 名年龄<60 岁，54 名年龄≥60 岁）在 HZO 发病时。
在 3 个月、6 个月和 1 年时记录眼前段并发症、治疗和手术情况，然后在随访期间的剩余时间每年记录一次。
眼压、炎症、类固醇使用、手术、眼前段并发症、疱疹后神经痛和延迟性带状疱疹假树突。
年轻组和老年组 HZO 患者的数量相等（分别为 51.8%，n=58 例和 48.2%，n=54 例，P=0.69）。HZO 发病最常见的十年是 50 岁至 59 岁之间。与老年患者相比，年轻患者更健康（P=0.05）。年轻患者更常见延迟性带状疱疹假树突（36.7%比 16.7%，P=0.03）。年轻患者的平均每年发病情次数明显更高（Z 检验，P=0.024）。老年患者更常发生疱疹后神经痛、神经营养性角膜病变和继发性感染性角膜炎（P=0.05）。两组患者的角膜穿孔、角膜变薄、白内障形成和青光眼的发生率相似。两组患者中（年轻患者 84.2%，老年患者 89.5%）在转诊后 3 年均有多数患者（84.2%的年轻患者和 89.5%的老年患者）使用局部皮质类固醇。
带状疱疹性眼病影响<60 岁和≥60 岁的个体数量相似，最常见的发病十年在 50 岁至 59 岁之间。与老年患者相比，年轻患者的延迟性假树突状角膜炎和炎症发作次数更多，而老年患者的神经营养性角膜病变问题更多。
