Quebec Heart and Lung Institute/Research Center, Québec, Québec, Canada.
Clin Pharmacol Ther. 2010 Apr;87(4):407-16. doi: 10.1038/clpt.2009.311. Epub 2010 Mar 3.
Obesity, a highly prevalent condition, is heterogeneous with regard to its impact on cardiovascular disease (CVD) risk. Epidemiological observations and metabolic investigations have consistently demonstrated that the accumulation of excess visceral fat is related to an increased risk of CVD as well as several metabolic and inflammatory perturbations. In the past decade, data from several studies have served to emphasize that atherosclerosis has an inflammatory component that may contribute to several key pathophysiological processes. Study data have also highlighted the finding that the expanded visceral fat is infiltrated by macrophages that conduct "cross-talk" with adipose tissue through several significant mechanisms. In this review, we provide, in the context of CVD risk, an up-to-date account of the complex interactions that occur between a dysfunctional adipose tissue phenotype and inflammation.
肥胖是一种高发疾病，其对心血管疾病（CVD）风险的影响存在异质性。流行病学观察和代谢研究一致表明，过多内脏脂肪的积累与 CVD 风险增加以及多种代谢和炎症紊乱有关。在过去的十年中，来自多项研究的数据强调了动脉粥样硬化具有炎症成分，可能有助于几个关键的病理生理过程。研究数据还突出了这样一个发现，即扩张的内脏脂肪被巨噬细胞浸润，巨噬细胞通过几种重要机制与脂肪组织进行“交叉对话”。在这篇综述中，我们根据 CVD 风险，提供了一个最新的关于功能失调的脂肪组织表型和炎症之间发生的复杂相互作用的描述。
