Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Department of Cardiology, Kailuan General Hospital, 57 Xinhua East Rd, Tangshan, 063000, People's Republic of China.
Nutr J. 2024 Nov 28;23(1):149. doi: 10.1186/s12937-024-01048-7.
The indicators of abdominal obesity have shown to be associated with a high risk of cardiovascular diseases (CVDs), even adjusted for body mass index (BMI). We aimed to investigate the association between neck circumference, waist-to-height ratio (WHtR), Chinese visceral adiposity index (CVAI) and incident heart failure (HF) in Chinese adults.
The current study included 86,546 participants from two independent cohorts: the Kailuan I study established in 2006 and the Kailuan study II established in 2008. Participants aged 18-80 years who were free of CVDs or cancer were recruited at baseline. The values of neck circumference, WHtR and CVAI were available in 2014. The trajectory analysis was conducted using repeated measures of WHtR and CVAI in the 2008, 2010, 2012 and 2014 surveys. The incident HF cases were identified via reviewing medical records by cardiologists.
During a mean follow-up of 5.62 years, 724 incident HF cases were documented. The highest quartiles of neck circumference, WHtR and CVAI respectively, were significantly associated with a high risk of HF compared to the lowest quartiles of adiposity measures (neck circumference: HR:1.30, 95%CI: 1.03-1.65; WHtR: HR:1.49, 95%CI: 1.16-1.92; and CVAI: HR:1.98, 95%CI: 1.48-2.65). The combination of adiposity measures with BMI or metabolic abnormalities jointly predicted incident HF. Presence of hypertension and diabetes appeared to be the major mediators, accounting for ∼ 8.11-24.7% of the associations between three indicators of abdominal obesity and HF risk.
The new indices of abdominal adiposity could help to identify those who were at a high risk of HF, especially in the presence of high BMI or metabolic abnormalities.
腹部肥胖的指标已被证明与心血管疾病（CVDs）的风险增加有关，即使调整了体重指数（BMI）也是如此。我们旨在研究颈围、腰高比（WHtR）、中国内脏脂肪指数（CVAI）与中国成年人心力衰竭（HF）事件之间的关系。
本研究纳入了两个独立队列的 86546 名参与者：2006 年建立的开滦 I 研究和 2008 年建立的开滦研究 II。在基线时，招募了年龄在 18-80 岁之间且无 CVD 或癌症的参与者。2014 年可获得颈围、WHtR 和 CVAI 值。通过对 2008 年、2010 年、2012 年和 2014 年调查的 WHtR 和 CVAI 的重复测量进行轨迹分析。通过心脏病专家审查病历来确定 HF 事件的发生情况。
在平均 5.62 年的随访期间，记录了 724 例 HF 事件。与肥胖指标的最低四分位相比，颈围、WHtR 和 CVAI 的最高四分位数分别与 HF 风险的增加显著相关（颈围：HR：1.30，95%CI：1.03-1.65；WHtR：HR：1.49，95%CI：1.16-1.92；CVAI：HR：1.98，95%CI：1.48-2.65）。将肥胖指标与 BMI 或代谢异常结合起来共同预测 HF 事件的发生。高血压和糖尿病的存在似乎是主要的中介因素，占腹部肥胖三个指标与 HF 风险之间关联的 8.11-24.7%。
新的腹部肥胖指标有助于识别 HF 风险较高的人群，尤其是在 BMI 较高或存在代谢异常的情况下。
