Department of Immunology, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
Eur J Immunol. 2010 May;40(5):1418-27. doi: 10.1002/eji.200939898.
Human cytomegalovirus (hCMV) infection is usually asymptomatic but may cause disease in immunocompromised hosts. It has been reported that hCMV infection may shape the NK cell receptor (NKR) repertoire in adult individuals, promoting a variable expansion of the CD94/NKG2C+ NK cell subset. We explored the possible relationship between this viral infection and the expression pattern of different NKR including CD94/NKG2C, CD94/NKG2A, immunoglobulin-like transcript 2 (ILT2, CD85j), KIR2DL1/2DS1, KIR3DL1, and CD161 in peripheral blood lymphocytes from healthy children, seropositive (n=21) and seronegative (n=20) for hCMV. Consistent with previous observations in adults, a positive serology for hCMV was associated with increased numbers of NKG2C+ NK and T cells as well as with ILT2+ T lymphocytes. Moreover, the proportions of CD161+ and NKG2C+CD56-CD3- NK cells also tended to be increased in hCMV+ individuals. Excretion of the virus was associated with higher proportions of NKG2C+ NK cells. Altogether, these data reveal that hCMV may have a profound influence on the NKR repertoire in early childhood.
人巨细胞病毒（hCMV）感染通常无症状，但可能在免疫功能低下的宿主中引起疾病。据报道，hCMV 感染可能会影响成人 NK 细胞受体（NKR）的组成，从而促进 CD94/NKG2C+NK 细胞亚群的可变扩增。我们探讨了这种病毒感染与不同 NKR 表达模式之间的可能关系，这些 NKR 包括外周血淋巴细胞中的 CD94/NKG2C、CD94/NKG2A、免疫球蛋白样转录物 2（ILT2、CD85j）、KIR2DL1/2DS1、KIR3DL1 和 CD161，来自健康儿童（n=21）、hCMV 血清阳性（n=20）和血清阴性（n=20）。与成人的先前观察一致，hCMV 的阳性血清学与 NKG2C+NK 和 T 细胞数量的增加以及 ILT2+T 淋巴细胞有关。此外，hCMV+个体中 CD161+和 NKG2C+CD56-CD3-NK 细胞的比例也有增加的趋势。病毒的排泄与更高比例的 NKG2C+NK 细胞有关。总之，这些数据表明 hCMV 可能对儿童早期的 NKR 组成有深远的影响。
