Fukuda M, Matsumoto K, Kojima S, Matsuyama T, Maeda H, Akatsuka Y, Tsuzuki S, Sughara T, Minami S, Kodera Y
Division of Hematology-Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital.
Rinsho Ketsueki. 1991 Jan;32(1):24-8.
In 6 of 27 patients in whom major ABO incompatible marrow was transplanted, the recovery of red blood cells (reticulocyte count greater than or equal to 1%) required more than 50 days after the transplantation. In 3 of them, more than 100 days were required. High titers of pre-transplant anti-A or anti-B agglutinin correlated with the delay in red blood cell recovery (IgM: p less than 0.01, IgG: p less than 0.05). In all of the patients whose pre-transplant IgM titers were 4 or less, and whose IgG titers were 32 or less, the red blood cells recovered within 50 days. Administration of cyclosporine did not correlate with the delay in red blood cell recovery. All the patients finally developed red cell production within 8 months without any treatment.
在27例接受主要ABO血型不合骨髓移植的患者中，有6例红细胞恢复（网织红细胞计数大于或等于1%）在移植后需要50多天。其中3例需要100多天。移植前抗A或抗B凝集素的高滴度与红细胞恢复延迟相关（IgM：p<0.01，IgG：p<0.05）。在所有移植前IgM滴度为4或更低且IgG滴度为32或更低的患者中，红细胞在50天内恢复。环孢素的使用与红细胞恢复延迟无关。所有患者最终在8个月内未接受任何治疗的情况下出现了红细胞生成。
