Musani Muhammad Ayub, Farooqui Abu Noem, Usman Asad, Atif Sabeen, Afaq Salman, Khambaty Yousuf, Ahmed Layeeq
ENT Department, Abbasi Shaheed Hospital and KMDC, Karachi.
J Pak Med Assoc. 2009 Dec;59(12):823-5.
To determine the association of the Herpes Simplex virus Type-1 infection and Bell's palsy in patients treated at the outpatient department of a tertiary care center.
A prospective, observational study was carried out at the outpatient department of Medical and ENT units of Abbasi Shaheed Hospital, Karachi. Fifty patients were enrolled in the study with their informed and written consent, between 2006-2007. All were >12 years of age. They were diagnosed as having Bell's palsy and were investigated for serologic evidence of Herpes simplex virus (HSV). The IgG and IgM antibodies for HSV were identified in the blood samples at the Aga Khan University hospitals laboratory.
Of the 50 patients enrolled, 35 (70%) patients were IgG/IgM positive for the HSV stressing the etiological association of HSV with Bell's palsy.
The study suggests that a relationship exists between HSV infection and Bell's palsy. The information might prove helpful in hastening the recovery by modifying management guidelines in view of the results of this study.
确定在一家三级医疗中心门诊部接受治疗的患者中，1型单纯疱疹病毒感染与贝尔麻痹之间的关联。
在卡拉奇阿巴西·谢赫德医院的内科和耳鼻喉科门诊部进行了一项前瞻性观察研究。2006年至2007年期间，50名患者在获得知情并书面同意后被纳入研究。所有患者年龄均超过12岁。他们被诊断为患有贝尔麻痹，并接受了单纯疱疹病毒（HSV）血清学证据的调查。在阿迦汗大学医院实验室对血液样本中的HSV IgG和IgM抗体进行了鉴定。
在纳入的50名患者中，35名（70%）患者的HSV IgG/IgM呈阳性，强调了HSV与贝尔麻痹的病因学关联。
该研究表明HSV感染与贝尔麻痹之间存在关联。鉴于本研究结果，这些信息可能有助于通过修改管理指南来加速恢复。
