[美金刚治疗对接受多奈哌齐治疗的中重度阿尔茨海默病患者的影响]
[Effect of memantine treatment on patients with moderate-to-severe Alzheimer's disease treated with donepezil].
作者信息
Creţu Oana, Szalontay Andreea Silvana, Chiriţă Roxana, Chiriţă V
机构信息
Secţia Psihiatrie VII acuţi, Spitalul Clinic de Psihiatrie "Socola" Iaşi.
出版信息
Rev Med Chir Soc Med Nat Iasi. 2008 Jul-Sep;112(3):641-5.
OBJECTIVE
Investigating the behavioral and cognitive effect of memantine in moderate to severe patients with Alzheimer's disease receiving donepezil.
MATERIAL AND METHOD
43 patients were enrolled in this prospective, randomized, parallel group study. There were no significant imbalances between the treatment groups in demographic and baseline clinical characteristics. Cognitive and global measures were collected at baseline and at the end of weeks 4, 8, 12 and 24. Behavioral measures were collected at baseline, at the end of week 12 and at week 24.
RESULTS
Memantine--treated patients showed significantly less deterioration in their functionality. Of patients who exhibited agitation/aggression at baseline, those treated with memantine and donepezil showed significant reduction of symptoms compared with donepezil--treated patients.
CONCLUSIONS
Treatment with memantine was well tolerated and reduced agitation/aggression, irritability, and appetite eating disturbances in patients who were agitated at baseline and delazed its emergence in those who were free of agitation at baseline.
目的
研究美金刚对接受多奈哌齐治疗的中重度阿尔茨海默病患者行为和认知的影响。
材料与方法
43例患者纳入这项前瞻性、随机、平行组研究。治疗组在人口统计学和基线临床特征方面无显著失衡。在基线以及第4、8、12和24周结束时收集认知和整体测量数据。在基线、第12周结束时和第24周收集行为测量数据。
结果
接受美金刚治疗的患者功能恶化明显较少。在基线时表现出激越/攻击行为的患者中，接受美金刚和多奈哌齐治疗的患者与仅接受多奈哌齐治疗的患者相比，症状显著减轻。
结论
美金刚治疗耐受性良好，可减轻基线时有激越症状患者的激越/攻击行为、易怒和食欲进食障碍，并延缓基线时无激越症状患者出现这些症状。
Zotero 插件